Chen X

BACKGROUND: The risk of ectopic pregnancy (EP) is known to increase with assisted reproductive technology (ART), but the specific risk factors are unclear. METHODS: We screened 6872 cycles for clinical data that met our study's inclusion c…

BACKGROUND: Substantial impacts on the female reproductive system have been definitively linked to heightened levels of serum uric acid. However, evidence directly linking increased serum uric acid levels to endometriosis in women remains s…

Antibiotic use is known to contribute to the development of osteoporosis, although the exact mechanisms remain poorly understood. Metronidazole (MET), a commonly prescribed antibiotic for treating anaerobic infections, has been linked to al…

OBJECTIVE: To develop and validate a nomogram prediction model for chronic pain after hysterectomy for uterine fibroids. METHODS: A retrospective study was conducted on 315 patients who visited our hospital from January 2022 to July 2024. …

The accumulation of regulatory T cells (Tregs) in the tumor microenvironment is a key factor for immunosuppression and immune escape of cancer cells. Genistein is a natural isoflavonoid in soybeans, possessing a wide range of pharmacologica…

Recent advances in understanding the modulatory functions of gut and gut microbiota on human diseases facilitated our focused attention on the contribution of the gut to the pathophysiological alterations of many extraintestinal organs, inc…

Gynecologic postoperative adhesions (GPOA) remain an under-appreciated source of morbidity despite advances in minimally invasive surgery. Adhesions forming after myomectomy, extensive endometriosis excision, repeat caesarean section, or hy…

BACKGROUND: Endometriosis is a common disease among women of childbearing age. However, the molecular mechanism behind it is still unknown. Therefore, new biomarkers and therapeutic targets are needed to improve the diagnosis and treatment …

OBJECTIVE: The aim of this study was to evaluate the impact of assisted reproductive technology (ART) on the risk of cerebral palsy (CP) in offspring. METHODS: We searched PubMed, Embase, Web of Science and Scopus databases for observation…

OBJECTIVE: This study aimed to develop a machine learning (ML) model integrated with SHapley Additive exPlanations (SHAP) analysis to predict postpartum hemorrhage (PPH) following vaginal deliveries, offering a potential tool for personaliz…

BACKGROUND: Chronic endometritis (CE) has been widely recognized as a potential cause of infertility, however, access to effective treatment is a formidable challenge due to the rudimentary understanding of the pathogenesis of persistent CE…

Ageing of the endometrium is a critical factor that affects reproductive health, yet its intricate mechanisms remain poorly explored. In this study, we performed transcriptome profiling and experimental verification of endometrium and endom…

Document-level biomedical relation extraction (BioDocuRE) is essential for biomedical knowledge discovery, as many factual relationships between biomedical entities span multiple sentences or even the entire document. Despite recent advance…

High incidence of unexplained miscarriage (UM) limits global human reproduction. Lithium (Li) batteries are widely used but rarely recycled, causing Li to spread into environments and enter human body. Notably, the healthy effects of Li exp…

INTRODUCTION: Ovarian cancer significantly contributes to cancer-related deaths among women. Resistance to anchorage-dependent cell death (anoikis) plays a vital role in facilitating metastasis and worsening patient prognosis. Recent develo…

BACKGROUND: Human Papillomavirus (HPV) infection is a ubiquitous sexually transmitted infection globally, frequently associated with sexual behaviors characterized by increased frequency and multiple partnerships. The relationship between v…

Expanding in vitro fertilization (IVF) access requires improved patient counseling and affordability via cost-success transparency. Clinicians ask how two types of live birth prediction (LBP) models perform: machine learning, center-specifi…

BACKGROUND: Endometriosis (EMs) is a persistent inflammatory condition whose three main symptoms, mass, pain, and infertility, severely affect female patients of childbearing age. Hu-Po-San (HPS), a preparation consisting of various herbal …

A thin endometrium can lead to low clinical pregnancy rates, low live birth rates, high spontaneous abortion rates, and low birth weight. However, current methods of treating thin endometria do not achieve ideal results. This study explored…

OBJECTIVE: This study investigates the role of the c-Fos/estrogen receptors (ERs)/mTOR pathway in lipid metabolism in human follicular granulosa cells of individuals with polycystic ovary syndrome (PCOS). Specifically, we aim to determine w…

The substantial apprehension facing young cancer patients revolves around the onset of chemotherapy-induced premature ovarian failure (POF), primarily linked to damage inflicted upon granulosa cells (GCs). The inquiry delves into the protec…

Non-invasive liquid biopsy is a promising strategy for ovarian cancer (OC) detection. We evaluated the feasibility and efficacy of a multi-analyte approach combining circulating tumor DNA (ctDNA) detection with protein biomarkers for early …

BACKGROUND: The National Natural Science Foundation of China (NSFC) plays a pivotal role in supporting basic medical research and shaping national funding priorities. As clinical and scientific demands in obstetrics and gynecology grow, par…

OBJECTIVE: To analyze the clinicopathological features and prognostic factors of intravenous Leiomyomatosis (IVL), a rare yet recurrent disease. METHODS: This retrospective observational study enrolled 43 patients with pathologically confi…

OBJECTIVES: This study aimed to dissect the aetiological subgroups of postpartum haemorrhage (PPH) that occur after vaginal delivery in women with full-term singleton pregnancies. Our goal was to craft and validate predictive models to guid…