Held K

No ORCID on file · 4 papers in corpus · active 2021-2026

Study types

  • other 3
other 2026
A duo of redox-sensitive pore-loop cysteines controls the activity of the neural ion channel TRPM3
Communications chemistry ·doi:10.1038/s42004-026-01889-9

Transient Receptor Potential Melastatin 3 (TRPM3) is a non-selective, Ca2+-permeable ion channel that plays a pivotal role in peripheral thermosensation and nociception. Moreover, gain-of-function variants in TRPM3 underlie a spectrum of ne…

other 2023
Gain-of-function variants in the ion channel gene TRPM3 underlie a spectrum of neurodevelopmental disorders
eLife ·doi:10.7554/eLife.81032

TRPM3 is a temperature- and neurosteroid-sensitive plasma membrane cation channel expressed in a variety of neuronal and non-neuronal cells. Recently, rare de novo variants in TRPM3 were identified in individuals with developmental and epil…

other 2023
Protease secretions by the invading blastocyst induce calcium oscillations in endometrial epithelial cells via the protease-activated receptor 2
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-023-01085-7

BACKGROUND: Early embryo implantation is a complex phenomenon characterized by the presence of an implantation-competent blastocyst and a receptive endometrium. Embryo development and endometrial receptivity must be synchronized and an adeq…

2021
TRPM3 in Brain (Patho)Physiology.
Frontiers in cell and developmental biology ·doi:10.3389/fcell.2021.635659

Already for centuries, humankind is driven to understand the physiological and pathological mechanisms that occur in our brains. Today, we know that ion channels play an essential role in the regulation of neural processes and control many …