Judith A.F. Huirne

OBJECTIVES: The reported prevalence of adenomyosis ranges widely due to different study populations, diagnostic tests and criteria. Categorizing the severity of disease may prove important. This study aims to develop a semi-quantifiable son…

OBJECTIVE: To study the impact of laparoscopic niche repair on subendometrial peristalsis in women with a large niche. METHODS: A explorative prospective cohort study that included women with a large niche (residual myometrium ≤ 3 mm), actu…

INTRODUCTION: A symptomatic uterine niche is a long-term complication after a cesarean section (CS). A group of international niche experts reached consensus on a standardized definition of a disorder caused by a symptomatic niche, named ce…

Objectives: Heavy menstrual bleeding, dysmenorrhea and subfertility are associated with adenomyosis, a benign uterine condition characterised by ectopic endometrium within the myometrium. Currently, diagnosing adenomyosis is challenging. Im…

Adenomyosis, a benign yet serious uterine condition, is highly prevalent but difficult to diagnose and assess using conventional B-mode ultrasound imaging. As the formation of adenomyosis involves angiogenesis and influences local microvasc…

Background : Many women suffer from undiagnosed pelvic pain, potentially due to pelvic neuropathies, but are often treated symptomatically without addressing underlying causes. Pelvic neuropathies can cause severe symptoms, affecting qualit…

In this review, a systematic literature search on the effectiveness and complication rates of ultrasound-guided and magnetic resonance-guided high-intensity focused ultrasound (USg-/MRgHIFU) for abdominal wall endometriosis (AWE) was conduc…

• Focal adenomyosis is a heterogeneous group of different entities. • Using sonographic features, five different types can be identified. • Correct identification of these forms may lead to new insights on symptoms and management of each of…

OBJECTIVES: (carbon dioxide) emission from the MRI scanner, MR-HIFU device, and the medication used, and analyzed solid waste produced during treatment. METHODS: emission based on the energy used by the MRI scanner and MR-HIFU device and th…

BACKGROUND: Abnormal uterine bleeding (AUB) has a significant socioeconomic impact since it considerably impacts quality of life. Therapeutic options are frequently based on trial and error and do not target disease aetiology. Pathophysiolo…

Fibroids are benign tumours of the myometrium and are the most common gynaecologic abnormality. Although most fibroids are asymptomatic, they can cause symptoms like heavy menstrual bleeding, pelvic pain, sexual dysfunction, pressure compla…

Abstract Study question What is the effect of anti-angiogenic therapy on adenomyosis in mice Summary answer Commencing treatment at six weeks with angiogenesis inhibitor axitinib successfully reduced the severity of adenomyosis by approxima…

Uterine peristalsis is the rhythmic wave-like motion of the subendometrial layer of the uterus. These contractions change throughout the menstrual cycle in terms of direction, frequency and amplitude, and can be analysed with various method…

The uterine junctional zone is the subendometrial area in the myometrium that contributes to peristalsis and aids in spermatozoa and blastocyst transport. Alterations in the appearance of the junctional zone on transvaginal sonography (TVS)…

BACKGROUND: Uterine disorders have clear overlapping symptoms and ultrasound discrimination is not always easy. Accurately measuring vascularity is of diagnostic and prognostic value. Power Doppler is limited to imaging only the larger vess…

OBJECTIVES: To evaluate whether the Morphological Uterus Sonographic Assessment (MUSA) features of adenomyosis need to be better defined and, if deemed necessary, to reach consensus on the updated definitions. METHODS: A modified Delphi pr…

There is evidence for increased angiogenesis in the (ectopic) endometrium of adenomyosis patients under the influence of vascular endothelial growth factor (VEGF). VEGF stimulates both angiogenesis and lymph-angiogenesis. However, informati…

Uterine disorders are often presented with overlapping symptoms. The microvasculature holds specific information important for diagnosing uterine disorders. Conventional sonography is an established diagnostic technique in gynecology, but i…

BACKGROUND: Adenomyosis commonly occurs with abnormal uterine bleeding (AUB) and is associated with subfertility and a higher miscarriage rate. Recent evidence showed abnormal vascularization in the endometrium in patients with adenomyosis,…