Kannan A

No ORCID on file · 5 papers in corpus · active 2016-2026

Study types

  • article 1

Condition tags

  • endometriosis 1
  • chronic_pelvic_pain 1
  • infertility 1
2026
Extracellular vesicle delivery of Myricetin suppresses ovarian cancer through mitochondrial dynamics by downregulating the ECM1/NF-κB/TGFβ signaling pathway.
Scientific reports ·doi:10.1038/s41598-026-46901-3

Ovarian cancer is classified as a female malignancy commonly known as a silent killer with no early detection symptoms. Extracellular matrix protein 1 (ECM1) is associated with the Epithelial-mesenchymal transition (EMT) and metastasis proc…

2023
Uterine-specific Ezh2 deletion enhances stromal cell senescence and impairs placentation, resulting in pregnancy loss.
iScience ·doi:10.1016/j.isci.2023.107028

Maternal uterine remodeling facilitates embryo implantation, stromal cell decidualization and placentation, and perturbation of these processes may cause pregnancy loss. Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that…

2022
Regulation of AKT Signaling in Mouse Uterus.
Endocrinology ·doi:10.1210/endocr/bqab233

17β-estradiol (E2) treatment of ovariectomized adult mice stimulates the uterine PI3K-AKT signaling pathway and epithelial proliferation through estrogen receptor 1 (ESR1). However, epithelial proliferation occurs independently of E2/ESR1 s…

2016
Chronic Exposure to Bisphenol A Affects Uterine Function During Early Pregnancy in Mice.
Endocrinology ·doi:10.1210/en.2015-2031

Environmental and occupational exposure to bisphenol A (BPA), a chemical widely used in polycarbonate plastics and epoxy resins, has received much attention in female reproductive health due to its widespread toxic effects. Although BPA has…

article 2016
Progesterone Alleviates Endometriosis via Inhibition of Uterine Cell Proliferation, Inflammation and Angiogenesis in an Immunocompetent Mouse Model
PloS one ·doi:10.1371/journal.pone.0165347

Endometriosis, defined as growth of the endometrial cells outside the uterus, is an inflammatory disorder that is associated with chronic pelvic pain and infertility in women of childbearing age. Although the estrogen-dependence of endometr…