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- endometriosis 2
- infertility 1
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Organoid technology has provided unique insights into human organ development, function, and diseases. Patient-derived organoids are increasingly used for drug screening, modeling rare disorders, designing regenerative therapies, and unders…
Epithelial and stromal communications are essential for normal uterine functions and their dysregulation contributes to the pathogenesis of many diseases including infertility, endometriosis, and cancer. Although many studies have highlight…
Although aggressive invasion and distant metastases are an important cause of morbidity and mortality in patients with endometrial cancer (EC), the requisite events determining this propensity are currently unknown. Using organotypic three-…
// Preety Bajwa 1 , Sarah Nielsen 2 , Janine M. Lombard 3,4 , Loui Rassam 2,3 , Pravin Nahar 3,5 , Bo R. Rueda 6 , J. Erby Wilkinson 7 , Richard A. Miller 8 and Pradeep S. Tanwar 1 1 Gynaecology Oncology Group, School of Biomedical Sciences…
The contribution of the stromal microenvironment to the progression of endometrial cancer has not been well explored. We have conditionally expressed a mutant allele of adenomatous polyposis coli (APC(cKO)) in murine uterine stroma cells to…
Leiomyomas and other mesenchymally derived tumors are the most common neoplasms of the female reproductive tract. Presently, very little is known about the etiology and progression of these tumors, which are the primary indication for hyste…