Santoro N

ObjectiveTo examine the relationship between the day of embryo cryopreservation and large for gestational age (LGA) infants in women undergoing frozen embryo transfers (FETs) after cryopreservation on days 2-7 after fertilization and to com…

ObjectiveTo evaluate the relationship between hysterectomy with and without ovarian conservation and the onset of ovarian failure using anti-müllerian hormone (AMH) levels and imputed final menstrual period (FMP).MethodsA total of 1,428 wom…

BackgroundA test that helps predict the time to the final menstrual period (FMP) has been sought for many years.ObjectiveTo assess the ability of antimullerian hormone (AMH) measurements to predictions the time to FMP.DesignProspective long…

ContextThe relationship between reproductive and cardiometabolic aging is unclear. It is unknown if the relationship differs across different clinical populations.ObjectiveTo determine whether markers of ovarian reserve are associated with …

Study questionAre intrauterine insemination (IUI) performance characteristics and post-processing total motile sperm count (TMC) related to live birth rate in couples with unexplained infertility?Summary answerPatient discomfort with IUI an…

ObjectiveTo study whether there is a difference in the prevalence of non-cavity-distorting uterine fibroids between infertile patients with polycystic ovary syndrome (PCOS) and those with unexplained infertility (UI).DesignA secondary analy…

ObjectiveEndometriosis is a chronic, estrogen dependent condition that affects 5-10% of reproductive aged women and is associated with pelvic pain and infertility. As the approach to therapy shifts from surgical ablation to pharmacological …

Perimenopause, or the menopausal transition, represents a period of time during which newly arising symptoms can present complex management decisions for providers. Many women present to care with complaints of hot flashes, vaginal and sexu…

Study questionDoes fertility-related quality of life (FertiQOL) differ by infertility diagnosis between women with polycystic ovary syndrome (PCOS) and their partners, compared with couples with unexplained infertility (UI)?Summary answerWo…

PurposeA symbiotic relationship between ovarian granulosa cells (GC) and the developing oocyte is critical. Genetic modulations in GC's can lead to reproductive insufficiency, highlighting the role of GC's in reproductive competence. Utiliz…

ObjectiveTo better understand the site and mode of action of aromatase inhibitors.DesignProspective study.SettingAcademic research environment.Patient(s)Five eumenorrheic (without polycystic ovary syndrome), early follicular phase women wit…

ObjectiveTo evaluate whether ethnicity is associated with involuntary childlessness and perceived reasons for difficulties in becoming pregnant.DesignCross-sectional analysis of baseline data from a longitudinal cohort.SettingMultiethnic, c…

ObjectiveTo investigate if a diagnosis of diminished ovarian reserve (DOR) is associated with a differential gene profile of ovarian granulosa cells (GCs) in infertile women undergoing in vitro fertilization (IVF).DesignProspective Cohort S…

ObjectiveTo evaluate whether adolescent obesity is associated with difficulties in becoming pregnant later in life.DesignCross-sectional analysis of baseline data from a longitudinal cohort.SettingMultiethnic, community-based observational …

MicroRNAs (miRNAs), a class of small noncoding RNAs that regulate gene expression, have fundamental roles in biological processes, including cell differentiation and proliferation. These small molecules mainly direct either target messenger…

BackgroundIn-vitro fertilization (IVF) with blastocyst as opposed to cleavage stage embryos has been advocated to improve success rates. Limited information exists on which to predict which patients undergoing blastocyst embryo transfer (BE…

BackgroundIn mouse endometrium, glycogen synthase kinase-3beta (GSK3beta) is a key enzyme controlling nuclear localization of cyclin D1. We developed a functional model of xenografted human endometrium to test whether similar mechanisms are…

ObjectiveTo determine if attempts to maximize oocyte yield during ovarian stimulation translates into improved outcome of in vitro fertilization (IVF) cycles.DesignRetrospective study.SettingAcademic tertiary care IVF center.Patient(s)806 d…