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Agonists of luteinizing hormone-releasing hormone (LHRH) induce a reversible hypoestrogenic state through the down-regulation of LHRH receptors and desensitization of the pituitary. Since endometrial implants are estrogen sensitive, LHRH ag…
Endometriose, d. h. das Vorhandensein von Gebärmutterschleimhaut außerhalb des Cavum uteri, ist eine Erkrankung, die ungefähr 10 % aller Frauen in der reproduktiven Lebensphase betrifft [1]. In den meisten Fällen befindet sich das ektope En…
In those clinical situations in which an immediate and profound suppression of gonadotrophins is desired, LHRH agonists have the disadvantage of producing an initial stimulatory effect on hormone secretion. Therefore, the use of GnRH antago…
Luteinizing hormone-releasing hormone (LHRH) plays a crucial role in controlling the ovarian cycle in women. By modification of the molecular structure of this decapeptide, analogues were synthesized with agonistic or antagonistic effects o…