D K Hapangama

No ORCID on file · 12 papers in corpus · active 2008-2021

Study types

  • article 9
  • letter 1
  • other 1
  • review 1

Condition tags

  • endometriosis 11
  • infertility 2
  • dysmenorrhea 1
  • chronic_pelvic_pain 1
  • adenomyosis 1
article 2021
Symptomatology and Serum Nuclear Magnetic Resonance Metabolomics; Do They Predict Endometriosis in Fertile Women Undergoing Laparoscopic Sterilisation? A Prospective Cross-sectional Study
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-021-00725-w

Endometriosis is a common, chronic inflammatory condition, thought to have a higher incidence in symptomatic women, yet, commonly associated symptoms do not always correlate with the presence or severity of disease and diagnosis requires su…

article 2020
Fallopian tube epithelial cells express androgen receptor and have a distinct hormonal responsiveness when compared with endometrial epithelium
Human Reproduction ·doi:10.1093/humrep/deaa177

STUDY QUESTION: How does steroid receptor expression, proliferative activity and hormone responsiveness of the fallopian tube (FT) epithelium compare to that of the endometrial epithelium? SUMMARY ANSWER: Proliferative indices, hormone rece…

article 2018
Abnormally located SSEA1+/SOX9+ endometrial epithelial cells with a basalis-like phenotype in the eutopic functionalis layer may play a role in the pathogenesis of endometriosis
Human Reproduction ·doi:10.1093/humrep/dey336

STUDY QUESTION: Is endometriosis associated with abnormally located endometrial basalis-like (SSEA1+/SOX9+) cells in the secretory phase functionalis and could they contribute to ectopic endometriotic lesion formation? SUMMARY ANSWER: Women…

review 2016
Implications of telomeres and telomerase in endometrial pathology
Human reproduction update ·doi:10.1093/humupd/dmw044

BACKGROUND: Eukaryotic chromosomal ends are linear and are protected by nucleoprotein complexes known as telomeres. The complex structural anatomy and the diverse functions of telomeres as well as the unique reverse transcriptase enzyme, te…

letter 2016
Letter to the Editor re: “Expression of CD56 in patients with adenomyosis and its correlation with dysmenorrhea” from F. Wang and colleagues
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2016.08.025
article 2015
Human endometrial epithelial telomerase is important for epithelial proliferation and glandular formation with potential implications in endometriosis
Human Reproduction ·doi:10.1093/humrep/dev267

STUDY QUESTION: How does regulation of telomerase activity (TA) in human endometrial epithelial cells (EEC) by ovarian hormones impact on telomere lengths (TL) and cell proliferation? SUMMARY ANSWER: Healthy endometrial epithelial cell prol…

article 2015
In silico,in vitroandin vivoanalysis identifies a potential role for steroid hormone regulation of FOXD3 in endometriosis-associated genes
Human Reproduction ·doi:10.1093/humrep/dev307

STUDY QUESTION: Can bioinformatics analysis of publically available microarray datasets be utilized in identifying potentially important transcription factors (TF) in the hormonal regulation of the endometrium? SUMMARY ANSWER: Systems integ…

other 2013
SSEA-1 isolates human endometrial basal glandular epithelial cells: phenotypic and functional characterization and implications in the pathogenesis of endometriosis
Human Reproduction ·doi:10.1093/humrep/det285

STUDY QUESTION: Can the basal epithelial compartment of the human endometrium be defined by specific markers? SUMMARY ANSWER: Human endometrial epithelial cells from the basalis express nuclear SOX9 and the cell-surface marker SSEA-1, with…

article 2011
Aberrant expression of metastasis-inducing proteins in ectopic and matched eutopic endometrium of women with endometriosis: implications for the pathogenesis of endometriosis
Human Reproduction ·doi:10.1093/humrep/der412

BACKGROUND: Endometriosis is a metastatic disease without obvious tumorigenesis. Expression of S100P, S100A4, osteopontin (OPN) or anterior gradient homologue 2 (AGR2) proteins can induce metastasis but fail to induce tumorigenesis per se. …

article 2010
Aberrant expression of regulators of cell-fate found in eutopic endometrium is found in matched ectopic endometrium among women and in a baboon model of endometriosis
Human Reproduction ·doi:10.1093/humrep/deq248

BACKGROUND: We have recently shown that women with endometriosis express an increased amount of telomerase and nucleolin, with concomitant loss of γ-H2AX in eutopic endometrium. To further examine these selected factors that regulate cell f…

article 2008
Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length
Human Reproduction ·doi:10.1093/humrep/den172

BACKGROUND: In order to test our hypothesis that endometriosis is associated with abnormal expression of telomerase and telomere lengthening in endometrium, we assessed endometrial expression of the human telomerase enzyme and telomere leng…

article 2008
Sustained replication in endometrium of women with endometriosis occurs without evoking a DNA damage response
Human Reproduction ·doi:10.1093/humrep/den416

BACKGROUND: To test our hypothesis that eutopic secretory phase endometrium from women with endometriosis is similar to proliferative phase endometrium from fertile women without endometriosis, we explored the expression of regulators of ce…