Chen CY

OBJECTIVE: To describe a rare case of spontaneous complete uterine rupture in a primigravida during pregnancy following a prior laparoscopic radiofrequency ablation (RFA) for adenomyosis, and to review pregnancy outcomes after RFA for adeno…

OBJECTIVE: To report a rare case of severe endometriosis complicated by deep vein thrombosis (DVT) and pulmonary embolism (PE) without hormone exposure, and review similar cases in the literature. CASE REPORT: A 44-year-old woman with seve…

BackgroundEndocrine-disrupting chemicals (EDCs) are pervasive in everyday environments. The impacts of these chemicals, along with EDC-related lifestyle and dietary habits on neurocognitive function, are not well understood.MethodsThe Chang…

The mechanism underlying the co-occurrence of major depressive disorder (MDD) and gynecological diseases remains unclear. This study aimed to investigate the familial co-aggregation and shared genetic loading between MDD and gynecological d…

Macrophages, pivotal components of the immune system, orchestrate host defense mechanisms in humans and mammals. Their polarization into classically activated macrophages (CAMs or M1) and alternatively activated macrophages (AAMs or M2) dic…

Population isolates such as those in Finland benefit genetic research because deleterious alleles are often concentrated on a small number of low-frequency variants (0.1% ≤ minor allele frequency < 5%). These variants survived the founding …

AimRefugee arrivals to Europe have numbered more than one million since 2015 with the majority arriving through Greece. The healthcare needs of refugees have placed strains on Greece's healthcare system which has already been affected by it…

Since the past decade, aspirin, a popular anti-inflammatory drug, has been increasingly studied for its potential antimicrobial and antibiofilm activity with promising results, but studies were limited to in vitro and in vivo investigations…

Miscarriage is a common, complex trait affecting ~15% of clinically confirmed pregnancies. Here we present the results of large-scale genetic association analyses with 69,054 cases from five different ancestries for sporadic miscarriage, 75…

The normal menstrual cycle requires a delicate interplay between the hypothalamus, pituitary and ovary. Therefore, its length is an important indicator of female reproductive health. Menstrual cycle length has been shown to be partially con…

LXA4 could inhibit the invasion and migration of ESC by down-regulating the NF-κB signaling-mediated autophagy.

Heritability estimation provides important information about the relative contribution of genetic and environmental factors to phenotypic variation, and provides an upper bound for the utility of genetic risk prediction models. Recent techn…

BackgroundPrevious studies assessing second primary malignancies (SPMs) after uterine cancer have been conducted in Western populations with conflicting results. This study aimed to define the incidence and risk of SPMs in Taiwanese patient…

Uterine leiomyomas (fibroids or myomas) are benign monoclonal tumors arising from the smooth muscle cells of the myometrium [1]. The symptoms attributed to myomas include heavy or prolonged menstrual bleeding, pelvic pressure and pain, and …

Uterine adenomyosis and/or adenomyoma is characterized by the presence of heterotopic endometrial glands and stroma within the myometrium, >2.5 mm in depth in the myometrium or more than one microscopic field at 10 times magnification from …

Adenomyosis is an oestrogen-dependent disease characterized by the invasion of endometrial epithelial cells into the myometrium of uterus, and angiogenesis is thought to be required for the implantation of endometrial glandular tissues duri…

Adenomyosis of the uterus is defined as the presence of endometrial tissue, including glands and stroma, situated at least 2.5 mm below the endometrial-myometrial junction and widely distributed within the myometrium layer of the uterus. Th…

BACKGROUND: To assess parameters of 3-dimensional power Doppler ultrasound in differentiating an endometrioma from other hypoechogenic adnexal cysts. METHODS: We collected 58 patients with classic-appearing endometriomas (homogeneous hypoec…

This retrospective study was conducted to evaluate the indications and complications for non-radical abdominal hysterectomy. Between 1 July 1990 and 30 June 1991, 176 women underwent abdominal hysterectomy in our Department. The indications…