Edgardo Somigliana

No ORCID on file · 332 papers in corpus · active 1995-2026

Study types

  • article 153
  • review 81
  • other 49
  • letter 16
  • meta-analysis 11

Condition tags

  • endometriosis 291
  • infertility 53
  • endometrioma 38
  • chronic_pelvic_pain 29
  • adenomyosis 28
  • dyspareunia 17
  • dysmenorrhea 16
  • bowel_endometriosis 15
  • die_deep_infiltrating 8
  • bladder_endometriosis 6
letter 2021
Fertility and sterility ·doi:10.1016/j.fertnstert.2021.01.005
review 2021
International journal of molecular sciences ·doi:10.3390/ijms22169033

According to a rich body of literature, immune cell dysfunctions, both locally and systemically, and an inflammatory environment characterize all forms of endometriosis. Alterations in transcripts and proteins involved in the recruitment of…

article 2021
·doi:10.1093/humrep/deab127.038

Abstract Abstract text Endometriosis can affect natural fertility by distorting pelvic anatomy and by causing local pelvic inflammation that affects the quality of the oocytes, the function of the tubes and the sperm capacity to fertilize. …

article 2021
Minerva obstetrics and gynecology ·doi:10.23736/s2724-606x.21.04711-0

Management of women with endometriosis in general is complex. It requires a multidisciplinary and tailored approach. The time of in-vitro fertilization (IVF) may be particularly complicated because women with the disease face peculiar addit…

article 2021
Reproductive biomedicine online ·doi:10.1016/j.rbmo.2021.08.011

Research questionWhat are the associations between endometriosis, pelvic pain symptoms, fatigue and sleep? Psychological health and quality of life in endometriosis patients with good versus bad quality of sleep were also examined.DesignThi…

article 2020
Fertility and sterility ·doi:10.1016/j.fertnstert.2020.10.030

ObjectiveTo estimate the frequency of spontaneous hemoperitoneum in pregnancy (SHiP) in women with endometriosis achieving pregnancy with in vitro fertilization (IVF).DesignRetrospective case series.SettingReferral academic assisted reprodu…

letter 2020
Fertility and sterility ·doi:10.1016/j.fertnstert.2019.12.020
article 2020
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-019-00068-7

Several pathogenetic mechanisms have been postulated to explain the association between endometriosis and subfertility. However, to date, definitive conclusions cannot be drawn. In this study, we hypothesized that the reduced exploitation o…

article 2020
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-019-00070-z

A consistent body of in vitro evidence supports a detrimental effect of endometriosis on ovarian steroidogenesis, in particular the synthesis of estrogens. However, clinical evidence is scanty and methodologically weak. This study aimed at …

retraction 2020
Fertility and sterility ·doi:10.1016/j.fertnstert.2020.09.001

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Authors. The entire group of …

letter 2020
Fertility and sterility ·doi:10.1016/j.fertnstert.2020.04.007
article 2020
Reproductive biomedicine online ·doi:10.1016/j.rbmo.2020.03.003

Research questionAvailable evidence shows that the presence of ovarian endometriomas does not interfere with the ovarian response to ovarian stimulation. However, the mean size of the endometriomas in these studies is generally small, and t…

other 2020
Fertility and sterility ·doi:10.1016/j.fertnstert.2019.10.019
review 2019
Climacteric : the journal of the International Menopause Society ·doi:10.1080/13697137.2018.1549213

The incidence of endometriosis in middle-aged women is not minimal compared to that in the reproductive age group. The treatment of affected women after childbearing age to the natural transition toward menopause has received considerably p…

letter 2019
Human Reproduction ·doi:10.1093/humrep/dez192

International audience

letter 2019
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2018-02494
article 2019
·doi:10.1002/uog.20969

Endometrioma decidualisation during pregnancy is a demanding clinical condition. Ultrasonographic features may mimic ovarian cancer and clinicians have to face the dilemma whether to operate or not a pregnant woman. Surgery during pregnancy…

other 2019
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719118777637

The present randomized controlled in vitro study was designed to evaluate the effects of the exposure of human cryopreserved oocytes to endometriotic fluid. Twenty-three women aged 36 (4) years donated a total of 147 vitrified supernumerary…

article 2019
European journal of obstetrics & gynecology and reproductive biology: X ·doi:10.1016/j.eurox.2019.100073

OBJECTIVE: Ovarian hyper-stimulation during IVF is associated with a significant raise in serum estrogens and one may expect detrimental effects on estrogen-dependent diseases such as endometriosis. However, available evidence from large ca…

article 2019
Human reproduction open ·doi:10.1093/hropen/hoz009

A network of endometriosis experts from 16 Italian academic departments and teaching hospitals distributed all over the country made a critical appraisal of the available evidence and definition of 10 suggestions regarding measures to be de…

article 2018
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719118766259

The immunomodulatory, anti-inflammatory, and antiproliferative properties of vitamin D have laid the basis for a possible function of this prohormone in the pathogenesis of endometriosis. The aim of this case-control study was to investigat…

article 2018
Fertility and sterility ·doi:10.1016/j.fertnstert.2018.01.037

ObjectiveTo assess the proportion of patients with symptomatic endometriosis satisfied with their medical treatment 12 months after enrollment in a stepped-care management protocol.DesignProspective, single-arm, self-controlled study.Settin…

article 2018
Human Reproduction ·doi:10.1093/humrep/dey104

Bowel surgery for colorectal endometriosis is being promoted to infertile women without severe sub-occlusive symptoms, with the objective of improving the likelihood of conception. Contrary to rectal shaving, bowel surgery involving full-th…

article 2018
Human Reproduction ·doi:10.1093/humrep/dey368

Elagolix, an orally active non-peptidic GnRH antagonist, has been approved by the Food and Drug Administration for the management of moderate to severe pain associated with endometriosis. As the degree of ovarian suppression obtained with e…

article 2018
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719117749759

The purpose of this study was to assess the proportion of patients satisfied with their treatment after a change from a low-dose oral contraceptive (OC) to norethisterone acetate (NETA) because of inefficacy of OC on pain symptoms. To this …