Bast RC Jr
No ORCID on file
· 11 papers in corpus
· active 1985-2019
Study types
- other 3
- review 2
Condition tags
- endometriosis 5
Top journals
Frequent coauthors
- Robert C. Bast 5
- Lu KH 3
- R C Knapp 2
- Miller MC 2
- Niloff JM 2
- J M Niloff 2
- Lambert-Messerlian G 2
- Knapp RC 2
- Moore RG 2
- E Scaetzl 1
2019
Purpose of reviewBoth conventional and novel approaches to early detection of ovarian cancer are reviewed in the context of new developments in our understanding of ovarian cancer biology.Recent findingsWhile CA125 as a single value lacks a…
2018
Early detection of ovarian cancer could reduce mortality by 10% to 30%. Effective screening requires high sensitivity (>75%) and extremely high specificity (99.7%). Clinical trials suggest the best specificity is achieved with 2-stage strat…
2018
2013
HE4 (human epididymis protein 4) is overexpressed in both ovarian and endometrial cancers. Levels of the shed HE4 protein are elevated in sera from ovarian and endometrial cancer patients. HE4 is less frequently elevated than cancer antigen…
other
2012
OBJECTIVE: The human epididymis protein 4 (HE4) is a novel biomarker for ovarian cancer. This study measured the HE4 and CA125 levels in women with benign gynecological disorders. STUDY DESIGN: Sera were obtained from women prior to surger…
2012
ObjectiveThe purpose of this study was to establish normal ranges for human epididymis protein 4 (HE4) serum levels in healthy women.Study designHE4 levels were measured in healthy women and analyzed by age, menopausal status, and pregnancy…
2011
Cytoreductive surgery and empirical combination chemotherapy have improved 5-year survival for ovarian cancer patients, but have not increased the overall rate of cure. Poor outcomes relate, at least in part, to late diagnosis and to the pe…
review
1998
Over the last 15 years, substantial progress has been made in understanding the potential and the limitations of the CA 125 assay. More than 2000 papers have been published concerning laboratory and clinical studies of CA 125. The original …
review
1989
CA 125 is an antigenic determinant on a high-molecular-weight glycoprotein recognized by a monoclonal antibody which was raised using an ovarian cancer cell line as an immunogen. During the last 5 years the studies reviewed in this paper ha…
other
1986
CA-125 is a high-molecular-weight glycoprotein that is expressed on the cell surface of some derivatives of embryonic coelomic epithelium. Based on results of an immunoradiometric assay developed to detect CA-125 in peripheral blood, 82% of…
other
1985
Recombinant leukocyte alpha interferon (rIFN-alpha A; Hoffmann-La Roche, Inc) was administered to 15 patients with recurrent or persistent ovarian carcinoma. All patients had been previously treated with surgery and combination chemotherapy…