Gourley C

No ORCID on file · 12 papers in corpus · active 2005-2025

Study types

  • other 2
  • case-report 1
  • review 1

Condition tags

  • endometriosis 4
2025
JAMA oncology ·doi:10.1001/jamaoncol.2024.6797

ImportanceAdvanced clear cell gynecological cancers (CCGCs) have a poor prognosis, with response rates to second-line chemotherapy less than 8%. Preliminary clinical activity with programmed cell death 1 protein (PD-1) inhibitors reported i…

other 2024
European journal of cancer (Oxford, England : 1990) ·doi:10.1016/j.ejca.2024.114205

INTRODUCTION: Concurrent non-serous endometrial and ovarian tumours are often managed clinically as two separate primary tumours, but almost all exhibit evidence of a genomic relationship. METHODOLOGY: This study investigates the extent of…

case-report 2022
Gynecologic oncology reports ·doi:10.1016/j.gore.2022.101076

It is well recognized that some patients with endometrioid gynecological cancers have tumors arising in multiple sites (ovary, endometrium, and endometriosis) at the time of diagnosis. Molecular analysis has helped discern whether these mul…

2022
British journal of cancer ·doi:10.1038/s41416-022-01874-8

BackgroundOvarian carcinosarcoma (OCS) is an uncommon, biphasic and highly aggressive ovarian cancer type, which has received relatively little research attention.MethodsWe curated the largest pathologically confirmed OCS cohort to date, pe…

review 2021
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society ·doi:10.1136/ijgc-2020-001656

Clear cell carcinoma of the ovary has distinct biology and clinical behavior. There are significant geographical and racial differences in the incidence of clear cell carcinoma compared with other epithelial ovarian tumors. Patients with cl…

2020
Cancers ·doi:10.3390/cancers12061647

The estrogen receptor (ER) has functionality in selected ovarian cancer subtypes and represents a potential target for therapy. The majority (>80%) of high grade serous, low grade serous and endometrioid carcinomas and many granulosa cell t…

2020
Gynecologic Oncology ·doi:10.1016/j.ygyno.2019.12.015

ObjectiveMucinous ovarian carcinoma (MOC) is an uncommon ovarian cancer histotype that responds poorly to conventional chemotherapy regimens. Although long overall survival outcomes can occur with early detection and optimal surgical resect…

2017
Cancer biology & medicine ·doi:10.20892/j.issn.2095-3941.2016.0092

[This corrects the article on p. 236 in vol. 13, PMID: 27458531.].

2016
Cancer biology & medicine ·doi:10.20892/j.issn.2095-3941.2016.0024

Epithelial ovarian cancer represents the most lethal gynecological malignancy in the developed world, and can be divided into five main histological subtypes: high grade serous, endometrioid, clear cell, mucinous and low grade serous. These…

2012
British journal of cancer ·doi:10.1038/bjc.2012.410

BackgroundOvarian cancer is frequently advanced at presentation when treatment is rarely curative. Response to first-line platinum-based chemotherapy significantly influences survival, but clinical response is unpredictable and is frequentl…

other 2012
The Lancet. Oncology ·doi:10.1016/S1470-2045(12)70029-3
2005
International journal of oncology ·doi:10.3892/ijo.26.6.1681

WWOX is a candidate tumour suppressor gene that exhibits LOH or homozygous deletion in several tumour types. As well as the predominant full-length transcript (variant 1) there also exist alternatively spliced transcripts found previously o…