Hughes L

No ORCID on file · 3 papers in corpus · active 2022-2025
2025
Pembrolizumab in Patients With Advanced Clear Cell Gynecological Cancer: A Phase 2 Nonrandomized Clinical Trial.
JAMA oncology ·doi:10.1001/jamaoncol.2024.6797

ImportanceAdvanced clear cell gynecological cancers (CCGCs) have a poor prognosis, with response rates to second-line chemotherapy less than 8%. Preliminary clinical activity with programmed cell death 1 protein (PD-1) inhibitors reported i…

2024
Shear wave elastography to assess stiffness of the human ovary and other reproductive tissues across the reproductive lifespan in health and disease†.
Biology of reproduction ·doi:10.1093/biolre/ioae050

The ovary is one of the first organs to show overt signs of aging in the human body, and ovarian aging is associated with a loss of gamete quality and quantity. The age-dependent decline in ovarian function contributes to infertility and an…

2022
Early β-hCG levels predict live birth after single embryo transfer.
Journal of assisted reproduction and genetics ·doi:10.1007/s10815-022-02606-w

PurposeSpecific serum beta human chorionic gonadotropin (β-hCG) parameters that can predict live birth after an embryo transfer have yet to be defined.MethodsWe performed a retrospective cohort study of 1,028 patients with a detectable β-hC…