Kesner JS

BackgroundThere is evidence that in-utero exposure to PBBs, and similar chemicals, are associated with several adverse reproductive health outcomes including altered pubertal timing. However, less is known about the effects of in-utero expo…

ImportanceDespite lack of evidence of their utility, biomarkers of ovarian reserve are being promoted as potential markers of reproductive potential.ObjectiveTo determine the associations between biomarkers of ovarian reserve and reproducti…

Essentially all women are exposed to polycyclic aromatic hydrocarbons (PAHs), formed during incomplete combustion of organic materials, including fossil fuels, wood, foods, and tobacco. PAHs are ovarian toxicants in rodents, and cigarette s…

Persistent organohalogens (POHs) and metals have been linked to alterations in menstrual cycle function and fertility in humans. The Cree First Nations people living near James Bay in Ontario and Quebec, Canada, have elevated levels of POHs…

High serum follicle-stimulating hormone (FSH) levels have been associated with diminished ovarian reserve; however, the association between high urinary FSH and reduced natural fertility has yet to be established. We sought to characterize …

ObjectiveTo generate estimates of the association between markers of ovarian aging and natural fertility in a community sample at risk for ovarian aging.MethodsWomen aged 30-44 years with no history of infertility who had been trying to con…

ContextContinuous oral contraception may better suppress the ovary and endometrium, lending itself to the treatment of other medical conditions.ObjectiveOur objective was to determine the effects of continuous vs. cyclical oral contraceptio…

Hydrocarbons (HCs) found in fuels and solvents are ubiquitous in the environment, yet we know little about their effects on the endocrine system. The objective of this study was to assess the potential reproductive endocrine effects of low-…