Li X

Wen Shi,1–3,* Minyi Wang,1–3,* Zhuang Jin,1–3 Xiaochuan Chen,1–3 Jinbo Li,1–3 Huiling Lai,1–3 Xiao Li,1–3 Qiyu Zhong,1–3 Ye Chen,1–3 Shuqin Chen1–3 1Department of Gynecolog…

Sex hormone related disorders, characterized by complex etiology and long-term health risks, pose a significant challenge to global health. Hormone-based therapies are often accompanied by adverse effects and fail to address the underlying …

OBJECTIVE: Defective endometrial receptivity is an indispensable cause of infertility in endometriosis, yet the post-transcriptional regulatory mechanisms underlying this impairment remain poorly understood. The goal of this research was to…

The hypothalamus plays a vital role in reproductive processes. Previous studies have identified hypothalamic miRNAs involved in mammalian reproduction, but the miRNA profiles induced by photoperiod changes remain unclear. In this study, we …

For women with diminished ovarian reserve or of advanced age, controlled ovarian stimulation presents a significant challenge during in vitro fertilization cycles. This multi-center, open-label, randomized controlled trial enrolled 318 wome…

Endometrial polyps (EPs) are common uterine lesions associated with abnormal uterine bleeding and infertility, yet their pathogenesis remains poorly defined. Here, we performed single-cell RNA sequencing of normal endometrium, para-polyp, a…

BACKGROUND: Deep infiltrating endometriosis (DIE) is a highly fibrotic and deeply invasive subtype of endometriosis that causes severe pelvic pain, infertility and marked impairment of quality of life. Metabolic, microbial and immune distur…

BackgroundCervical clear cell adenocarcinoma (CCAC) and cervical endometrioid adenocarcinoma (CEAC) are rare and aggressive non-HPV-associated malignancies. Despite their histological similarities, these subtypes demonstrate distinct biolog…

Endometriosis is a benign yet aggressive disease characterized by enhanced proliferation and invasion of ectopic endometrial tissue. Identifying upstream regulators that co-regulate these processes will provide novel insights into endometri…

Endometriosis exhibits epithelial–mesenchymal transition (EMT)-aligned traits that promote invasion and lesion persistence. We investigated whether poly(ADP-ribose) polymerase-1 (PARP-1) coordinates β-catenin/TCF4 activity with EMT programs…

Background and objectivePoly(ADP-ribose) polymerase inhibitors (PARPis) have fundamentally changed the treatment paradigm for patients with ovarian cancer, especially in tumors with homologous recombination deficiency (HRD). However, acquir…

Adenomyosis is a prevalent disorder of the archimetra, historically conflated with endometriosis but possessing a unique pathobiological trajectory. This review synthesises current molecular evidence to propose a unified mechanistic framewo…

Primary vaginal cancer is a rare malignant tumor; its pathogenesis remains unclear and only a limited number of cases have been documented in the literature. The present report outlines a rare case of primary vaginal endometrioid adenocarci…

BackgroundThe relationship between the vascular flow index (VFI) of the endometrium and the pregnancy outcome in the frozen embryo transfer (FET) cycle remains controversial, and there is currently no recommended optimal range for VFI.Objec…

Precancers, defined as normal-appearing or morphologically altered tissues with a risk of oncogenesis, exhibit various detectable manifestations across anatomical sites, including epithelial dysplasia, metaplasia, hyperplasia, and stromal f…

Oral delivery of protein and peptide therapeutics (PPs) offers a non-invasive, patient-friendly alternative to parenteral administration, yet faces multiple formidable barriers due to the complex gastrointestinal (GI) environment. This revi…

Biofilm accumulation and subsequent implant-related infections pose significant challenges in the biomedical field. Photocatalytic coatings hold promise for antimicrobial efficacy; however, their effectiveness in dynamic polymicrobial infec…

ObjectiveTo investigate the interaction effects of anti-Müllerian hormone (AMH), antral follicle count (AFC), basal follicle-stimulating hormone (FSH), and endometrial thickness on the outcomes of assisted reproductive technology (ART).Meth…

ObjectiveTo investigate the impact of thyroid autoimmunity (TAI) on fertilization outcomes in euthyroid infertile women undergoing in vitro fertilization-embryo transfer (IVF-ET), and to identify key follicular fluid exosomal miRNAs associa…

Tumor immune escape is a major challenge in cancer treatment, and targeted immune escape therapy has become a key strategy for cancer treatment. As an important deubiquitinating enzyme, ubiquitin-specific protease 10 (USP10) participates in…

Adenomyosis is a chronic gynecological disorder characterized by ectopic endometrial tissue within the myometrium, leading to pelvic pain, menorrhagia, and infertility. Increasing evidence implicates dysregulated Wnt/beta-catenin signaling …

Background/Objective: RNA modifications, including N6-methyladenosine (m6A), 5-methylcytosine (m5C), 7-methylguanosine (m7G), N1-methyladenosine (m1A), pseudouridine (Ψ), N4-acetylcytidine (ac4C), 5-methoxycarbonylmethyl-2-thiouridine (mcm5…

OBJECTIVE: To evaluate the effects of a three-stage treatment strategy featured by cold-knife adenomyomectomy, enhanced endometrial protection and postoperative uterine monitoring for severe diffuse adenomyosis on IVF/ICSI and perinatal out…