Jae Hoon Lee

Endometriosis is a common disease in reproductive aged women, and it detrimentally affects patients' quality of life and fertility. Moreover, because of the complexity of the disease itself, proper effective management is difficult. Within …

Background: Repair of DNA double strand break (DSB) is an important mechanism for maintaining genetic stability during a DNA damage event. Although, a growing body of recent evidence suggests that DNA DSBs and related repair mechanisms may …

This study aimed to assess whether dienogest (DNG) is also effective in patients with recurrent endometriosis based on multicenter data of 121 women who were clinically diagnosed as having recurrent endometriosis and treated for more than 2…

Among the several components in Korean red ginseng, the saponin components are known to have various pharmacologic activities. The objective of this study was to evaluate therapeutic effects of saponin extracts from Korean red ginseng on en…

AIMS: Our objective was to predict natural pregnancy after endometriosis surgery using the endometriosis fertility index (EFI). METHODS: A retrospective medical records review was conducted, examining patients surgically treated for endome…

This research aimed to evaluate the potential therapeutic effects of Rg3 on endometriosis and identify target miRNAs. We designed an in vitro study using human endometrial stromal cells (HESCs) obtained from patients with endometriosis and …

OBJECTIVE: The aim of this study was to evaluate the effectiveness of postoperative levonorgestrel-releasing intrauterine system (LNG-IUS) insertion after gonadotropin-releasing hormone agonist (GnRH-a) treatment for preventing endometrioti…

To investigate the effects of trichostatin A (TSA) on nonsteroidal anti-inflammatory drug-activated gene 1 (NAG-1) expression and apoptosis in human endometriotic stromal cells (HESCs), ectopic endometrial tissues were obtained from 15 pati…

OBJECTIVE: To investigate the effect of peroxisome proliferator activated receptor γ (PPARγ) agonist on the cell proliferation properties and expression of human telomerase reverse transcriptase (hTERT) and aromatase in cultured endometrial…

Examination of 631 infertile women, including 434 women with endometriosis and 197 without endometriosis, revealed an increasing incidence of endometrial polyps, especially in the test subjects with endometriosis, and advanced stages of end…

AIMS: To investigate whether the GnRH agonist may reduce aromatase P450 and COX-2 in the eutopic endometrium of patients with endometriosis and ovarian endometrioma. MATERIALS AND METHODS: Endometrial specimens and ovarian endometrioma wer…

목적: 성선자극호르몬 분비호르몬 효능제가 자궁내막증의 중요한 병인으로 생각되는 아로마타제와 COX-2에 직접적인 작용이 있는지를 생체 내 뿐 아니라, 난소 자궁내막종과 자궁내막증 환자의 자궁내막의 기질 세포 배양을 통해 알아보고자 하였다. 연구 방법: 불임 클리닉을 내원한 환자들 중 복강경 수술을 요하는 환자군을 대상으로 전향적 연구를 실시하였다. 복강경수술 상 난소에 자궁내막종이 보이면 낭종적출술 (enucleation)을 …