Paolo Vercellini

OBJECTIVE: To synthesize the available evidence on abdominal wall endometriosis (AWE) after cesarean section (CS) by characterizing its clinical features and timing of presentation, and to determine how often prior or concomitant endometrio…

UNLABELLED: Introduction: In recent years, dietary supplements have emerged as popular "natural" alternatives to conventional pharmacological treatments for various conditions, including endometriosis. The growing popularity of supplements …

OBJECTIVES: Endometriosis and endometrial polyps are both estrogen-dependent conditions, and an association between these two pathologies has been observed in infertile women. Our research question was: "Is there an association between endo…

Endometriosis, particularly ovarian endometrioma, is associated with a 2-fold increased risk of ovarian cancer (OC), especially the clear cell and endometrioid subtypes. However, the absolute lifetime risk of OC in women with endometriosis …

STUDY QUESTION: Are there histological and immunohistochemical patterns of superficial peritoneal endometriotic lesions of symptomatic patients that characterize non-response to dienogest treatment and may suggest progesterone resistance? …

INTRODUCTION: Women with endometriosis frequently experience psychological and sexual concerns. Combined oral contraceptives (COCs) and progestin-only pills (POPs) represent first-line treatments for the disease, yet their potential negativ…

The link between endometriosis and other medical conditions is gaining attention. Such insights could enhance clinical approaches to manage the disease and potentially reveal new, unrecognized mechanisms of its development. The aim of this …

STUDY QUESTION: Are endometriotic lesions affecting bilateral organs or anatomical structures distributed symmetrically on both sides of the body? SUMMARY ANSWER: The left-sided preponderance of pelvic endometriotic lesions, and the right-…

Endometriosis is associated with nociceptive pain, as well as peripheral and central sensitization. Evidence-based treatment suggestions for controlling endometriosis should be based on the convergence of the best scientific evidence, physi…

Endometriosis is associated with nociceptive pain and with peripheral as well as central sensitization. To relieve nociceptive pain, most symptomatic patients benefits from hormonal therapy, which includes first-line (progestogens and estro…

BACKGROUND: Symptoms of endometriosis often emerge during adolescence and intensify in early adulthood, critical periods for educational and career development. However, evidence on its impact on women’s broader life trajectories, particula…

Background/Objectives: The scientific community is still divided between supporters of the implantation theory and researchers who advocate the theory of coelomic metaplasia/embryonic cell remnants to explain the initiation of endometriosis…

Endometriosis can impair natural reproduction through multiple mechanisms, including distortion of pelvic anatomy and chronic peritoneal inflammation. On this basis, surgical treatment might be reasonably expected to benefit. However, clini…

Across studies, the percentage of individuals reporting regularly engaging in menstrual coitus ranges between 4% and 43%. Although no clinical guideline recommends avoiding sexual activity during menstruation, according to some researchers …

BACKGROUND: Endometriosis presents diagnostic challenges and has profound impacts, encompassing physical and psychological symptoms, relationship difficulties, and disruptions in daily life. The emotional burden is pervasive, intensified by…

Background: Endometriosis and uterine fibroids are estrogen-dependent gynecological disorders with an increasing burden to women's health worldwide. Despite overlapping symptoms and long-term consequences, the magnitude of their co-occurren…

In their thought-provoking commentary, Hudelist et al.1 highlighted the inconsistent association between endometriosis and chronic pelvic pain. They warned that the origin of symptoms may be multifactorial and not always due to the presence…

Moreira and Oliveira highlight the shortcomings of the current management of endometriosis symptoms based on exclusively lesion-centred models, and promote patient categorisation according to an individual's predominant neurobiological mech…