Takao Kobayashi

No ORCID on file · 7 papers in corpus · active 2015-2026

Study types

  • rct 3
  • article 2
  • other 2

Condition tags

  • endometriosis 4
  • dysmenorrhea 2
  • chronic_pelvic_pain 1
  • adenomyosis 1
rct
Efficacy and safety of estetrol (15 mg)/drospirenone (3 mg) combination in a cyclic regimen for the treatment of primary and secondary dysmenorrhea: a multicenter, placebo-controlled, double-blind, randomized study
Fertility and sterility ·doi:10.1016/j.fertnstert.2024.11.003

OBJECTIVE: To evaluate the efficacy and safety of the estetrol (E4) (15 mg)/drospirenone (DRSP) (3 mg) combination in a cyclic regimen in Japanese women with primary and secondary dysmenorrhea. DESIGN: A 16-week, multicenter, randomized, d…

other 2026
Impact of estetrol and drospirenone combination therapy on alleviation of the pelvic pain of endometriosis: a randomized control trial
F&S reports ·doi:10.1016/j.xfre.2025.12.002

OBJECTIVE: To study the impact of estetrol (E4), a novel native estrogen with selective tissue activity, on endometriosis-associated pelvic pain (EAPP) and global impressions of endometriosis pain. DESIGN: Multicenter, randomized, open-lab…

other 2026
Post Hoc Analysis of a Previous Study of Estetrol 15 mg/Drospirenone 3 mg Combination for Dysmenorrhea and Uterine Bleeding in Adenomyosis Patients
Reproductive medicine and biology ·doi:10.1002/rmb2.70021

PURPOSE: To clarify the efficacy and safety of the estetrol 15 mg/drospirenone 3 mg combination among Japanese women with adenomyosis by post hoc analyses of a previous randomized clinical study. METHODS: Post hoc analyses were performed u…

article 2026
TLH困難症例に対する施設内の新しい試み

At our hospital, we have incrementally expanded the indications for total laparoscopic hysterectomy (TLH) since its introduction in 2019. We report on our experience with a patient who had TLH for a cervical fibroid complicated by endometri…

rct 2024
Efficacy and safety of the combination of estetrol 15 mg/drospirenone 3 mg in a cyclic regimen for the treatment of endometriosis-associated pain and objective gynecological findings: a multicenter, placebo-controlled, double-blind, randomized study
Fertility and sterility ·doi:10.1016/j.fertnstert.2024.07.011

OBJECTIVE: To evaluate the efficacy and safety of 24-week cyclic administration of estetrol (E4) (15 mg)/drospirenone (DRSP) (3 mg) in Japanese patients with endometriosis. DESIGN: A 24-week, multicenter, randomized, double-blind, placebo-…

rct 2024
Impact of Estetrol Combined with Drospirenone on Blood Coagulation and Fibrinolysis in Patients with Endometriosis: A Multicenter, Randomized, Open-Label, Active-Controlled, Parallel-Group Study
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis ·doi:10.1177/10760296241286514

Venous thromboembolism is a serious safety concern in women using combined oral contraceptives; ethinyl estradiol (EE) is widely used as an estrogen. Estetrol (E4) is a native estrogen with selective tissue activity and exclusively produced…

article 2015
Risks of thromboembolism associated with hormonal contraceptives related to body mass index and aging in Japanese women
·doi:10.1016/j.thromres.2015.11.038