Zelenko Z

No ORCID on file · 6 papers in corpus · active 2011-2016

Study types

  • article 4

Condition tags

  • endometriosis 3
  • infertility 2
article 2016
Aberrant Endometrial DNA Methylome and Associated Gene Expression in Women with Endometriosis
Biology of reproduction ·doi:10.1095/biolreprod.116.140434

Endometriosis is an estrogen-dependent, progesterone-resistant disorder largely derived from retrograde transplantation of menstrual tissue/cells into the pelvis, eliciting an inflammatory response, pelvic pain, and infertility. Eutopic end…

2014
Human endometrial DNA methylome is cycle-dependent and is associated with gene expression regulation.
Molecular endocrinology (Baltimore, Md.) ·doi:10.1210/me.2013-1340

Human endometrium undergoes major gene expression changes, resulting in altered cellular functions in response to cyclic variations in circulating estradiol and progesterone, largely mediated by transcription factors and nuclear receptors. …

article 2012
Krüppel-Like Factor 9 and Progesterone Receptor Coregulation of Decidualizing Endometrial Stromal Cells: Implications for the Pathogenesis of Endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2011-2562

CONTEXT: Endometriosis is characterized by progesterone resistance and associated with infertility. Krüppel-like factor 9 (KLF9) is a progesterone receptor (PGR)-interacting protein, and mice null for Klf9 are subfertile. Whether loss of KL…

2012
Perivascular human endometrial mesenchymal stem cells express pathways relevant to self-renewal, lineage specification, and functional phenotype.
Biology of reproduction ·doi:10.1095/biolreprod.111.095885

Human endometrium regenerates on a cyclic basis from candidate stem/progenitors whose genetic programs are yet to be determined. A subpopulation of endometrial stromal cells, displaying key properties of mesenchymal stem cells (MSCs), has b…

article 2011
Biobanking human endometrial tissue and blood specimens: standard operating procedure and importance to reproductive biology research and diagnostic development
Fertility and sterility ·doi:10.1016/j.fertnstert.2011.01.164

ObjectiveTo develop a standard operating procedure (SOP) for collection, transport, storage of human endometrial tissue and blood samples, subject and specimen annotation, and establishing sample priorities.DesignThe SOP synthesizes sound s…

article 2011
Nuclear Receptor, Coregulator Signaling, and Chromatin Remodeling Pathways Suggest Involvement of the Epigenome in the Steroid Hormone Response of Endometrium and Abnormalities in Endometriosis
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719111415546

Human endometrium, a steroid hormone-dependent tissue, displays complex cellular regulation mediated by nuclear receptors (NRs). The NRs interact with histone-modifying and DNA-methylating/-demethylating enzymes in the transcriptional compl…