Hirasawa A

No ORCID on file · 7 papers in corpus · active 2010-2020

Study types

  • article 1
  • other 1

Condition tags

  • endometriosis 2
2020
Identification of a novel uterine leiomyoma GWAS locus in a Japanese population.
Scientific reports ·doi:10.1038/s41598-020-58066-8

Uterine leiomyoma is one of the most common gynaecologic benign tumours, but its genetic basis remains largely unknown. Six previous GWAS identified 33 genetic factors in total. Here, we performed a two-staged GWAS using 13,746 cases and 70…

2020
Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing.
Scientific reports ·doi:10.1038/s41598-020-69488-9

The use of primary patient-derived organoids for drug sensitivity and resistance testing could play an important role in precision cancer medicine. We developed expandable ovarian cancer organoids in < 3 weeks; these organoids captured the …

2018
ADAM9 is over-expressed in human ovarian clear cell carcinomas and suppresses cisplatin-induced cell death.
Cancer science ·doi:10.1111/cas.13469

ADAMs (a disintegrin and metalloproteinases) are involved in various biological events such as cell adhesion, migration and invasion, membrane protein shedding and proteolysis. However, there have been no systematic studies on the expressio…

other 2015
Clinicopathologic analysis with immunohistochemistry for DNA mismatch repair protein expression in synchronous primary endometrial and ovarian cancers
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society ·doi:10.1097/IGC.0000000000000377

OBJECTIVE: Synchronous primary endometrial and ovarian cancers have been an important topic in clinical medicine because it is sometimes difficult to distinguish whether there are 2 primary tumors or a single primary tumor and an associated…

2014
Features of ovarian cancer in Lynch syndrome (Review).
Molecular and clinical oncology ·doi:10.3892/mco.2014.397

Lynch syndrome is a hereditary ovarian cancer with a prevalence of 0.9-2.7%. Lynch syndrome accounts for 10-15% of hereditary ovarian cancers, while hereditary breast and ovarian cancer syndrome accounts for 65-75% of these cancers. The lif…

2013
Hypertriglyceridemia is frequent in endometrial cancer survivors.
Japanese journal of clinical oncology ·doi:10.1093/jjco/hyt125

ObjectivePrevious studies have reported an association between endometrial cancer and the risk of metabolic syndrome; however, the pattern of endometrial cancer-associated dyslipidemia is not well understood. The standard therapy for endome…

article 2010
A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese
Nature genetics ·doi:10.1038/ng.612

Although the pathogenesis of endometriosis is not well understood, genetic factors have been considered to have critical roles in its etiology. Through a genome-wide association study and a replication study using a total of 1,907 Japanese …