Pollard JW

No ORCID on file · 6 papers in corpus · active 2009-2020

Study types

  • article 1
  • preprint 1

Condition tags

  • endometriosis 2
preprint 2020
Macrophages inhibit and enhance endometriosis depending on their origin
·doi:10.1101/2020.04.30.070003

Abstract Macrophages are intimately involved in the pathophysiology of endometriosis, a chronic inflammatory disorder characterized by the growth of endometrial-like tissue (lesions) outside the uterus. By combining genetic and pharmacologi…

2017
Xenografted tissue models for the study of human endometrial biology.
Differentiation; research in biological diversity ·doi:10.1016/j.diff.2017.11.004

The human endometrium undergoes extensive morphological, biochemical and molecular changes under the influence of female sex steroid hormones. Besides the fact that estrogen stimulates endometrial cell proliferation and progesterone inhibit…

article 2015
Activation of protein synthesis in mouse uterine epithelial cells by estradiol-17β is mediated by a PKC–ERK1/2–mTOR signaling pathway
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.1418973112

The uterine epithelium of mice and humans undergoes cyclical waves of cell proliferation and differentiation under the regulation of estradiol-17β (E2) and progesterone (P4). These epithelial cells respond to E2 with increased protein and D…

2012
KLF15 negatively regulates estrogen-induced epithelial cell proliferation by inhibition of DNA replication licensing.
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.1118515109

In the epithelial compartment of the uterus, estradiol-17β (E(2)) induces cell proliferation while progesterone (P(4)) inhibits this response and causes differentiation of the cells. In this study, we identified the mechanism whereby E(2) a…

2010
Genomic profiling of microRNAs and messenger RNAs reveals hormonal regulation in microRNA expression in human endometrium.
Biology of reproduction ·doi:10.1095/biolreprod.109.081059

MicroRNAs (miRNAs), a class of small noncoding RNAs that regulate gene expression, have fundamental roles in biological processes, including cell differentiation and proliferation. These small molecules mainly direct either target messenger…

2009
Lithium chloride treatment induces epithelial cell proliferation in xenografted human endometrium.
Human reproduction (Oxford, England) ·doi:10.1093/humrep/dep115

BackgroundIn mouse endometrium, glycogen synthase kinase-3beta (GSK3beta) is a key enzyme controlling nuclear localization of cyclin D1. We developed a functional model of xenografted human endometrium to test whether similar mechanisms are…