Lei S

No ORCID on file · 8 papers in corpus · active 2018-2024

Study types

  • article 4
  • other 2
  • preprint 1

Condition tags

  • endometriosis 6
  • endometrioma 2
  • dysmenorrhea 1
  • chronic_pelvic_pain 1
  • infertility 1
  • adenomyosis 1
other 2024
Association between adenomyosis volume and adverse perinatal outcomes: multicenter cohort study
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology ·doi:10.1002/uog.29108

OBJECTIVE: To assess the association between adenomyosis volume, as a reflection of its severity, and the risk of adverse perinatal outcomes. METHODS: This multicenter retrospective cohort study was conducted at a comprehensive tertiary ca…

other 2024
Overexpressed nicotinamide N‑methyltransferase in endometrial stromal cells induced by macrophages and estradiol contributes to cell proliferation in endometriosis
Cell death discovery ·doi:10.1038/s41420-024-02229-3

Endometriosis, an estrogen-dependent chronic inflammatory condition, afflicts reproductive-aged women. However, the underlying pathological mechanisms remain to be elucidated. Nicotinamide N-methyltransferase (NNMT) is a critical enzyme inv…

article 2023
Gut dysbiosis-derived β-glucuronidase promotes the development of endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2023.03.032

OBJECTIVE: To explore the role of gut dysbiosis-derived β-glucuronidase (GUSB) in the development of endometriosis (EMs). DESIGN: 16S rRNA sequencing of stool samples from women with (n = 35) or without (n = 30) endometriosis and from a mo…

article 2022
Downregulating HK2 inhibits proliferation of endometrial stromal cells through a noncanonical pathway involving phosphorylation of signal transducer and activator of transcription 1 in endometriosis
Biology of reproduction ·doi:10.1093/biolre/ioac081

BACKGROUND: Endometriosis is a benign gynecologic disease that causes chronic pelvic pain, dysmenorrhea and infertility and shares several characteristics with malignant tumors, afflicting women of reproductive age. Hexokinase 2 plays an es…

article 2022
Hypoxia-hindered methylation of PTGIS in endometrial stromal cells accelerates endometriosis progression by inducing CD16- NK-cell differentiation
Experimental & molecular medicine ·doi:10.1038/s12276-022-00793-1

Prostacyclin (PGI2) plays key roles in shaping the immune microenvironment and modulating vasodilation, whereas its contribution to endometriosis (EMs) remains largely unclear. Our study suggested that prostacyclin synthase (PTGIS)-dependen…

preprint 2021
Down-Regulating Hexokinase 2 Inhibits Proliferation of Endometrial Stromal Cells Through a Noncanonical Pathway Involving Phosphorylated-STAT1 in Endometriosis
·doi:10.21203/rs.3.rs-845266/v1

Abstract Background: Endometriosis is a benign gynecologic disease that causes chronic pelvic pain, dysmenorrhea and infertility and shares several characteristics with malignant tumors, afflicting women of reproductive age. Hexokinase 2 (…

2021
Role of robotic natural orifice specimen extraction surgery in colorectal neoplasms.
Scientific reports ·doi:10.1038/s41598-021-89323-z

Natural orifice specimen extraction surgery (NOSES) is especially suitable for colorectal surgery. Until now, most of the reports published were about laparoscopic NOSES, the reports about robotic NOSES are extremely rare. This study aims t…

article 2018
H2S promotes proliferation of endometrial stromal cells via activating the NF-κB pathway in endometriosis.
American journal of translational research

S to treat endometriosis.