Experimental & molecular medicine

article 2022

Hypoxia-hindered methylation of PTGIS in endometrial stromal cells accelerates endometriosis progression by inducing CD16- NK-cell differentiation

doi:10.1038/s12276-022-00793-1 ·PMID:35781537

Prostacyclin (PGI2) plays key roles in shaping the immune microenvironment and modulating vasodilation, whereas its contribution to endometriosis (EMs) remains largely unclear. Our study suggested that prostacyclin synthase (PTGIS)-dependen…

article 2020

β-catenin activates TGF-β-induced epithelial–mesenchymal transition in adenomyosis

doi:10.1038/s12276-020-00514-6 ·PMID:33060769

Adenomyosis is defined as the presence of ectopic nests of endometrial glands and stroma within the myometrium. Adenomyosis is a common cause of dysmenorrhea, menorrhagia, and chronic pelvic pain but is often underdiagnosed. Despite its pre…

article 2018

Increased α2-6 sialylation of endometrial cells contributes to the development of endometriosis

doi:10.1038/s12276-018-0167-1 ·PMID:30542051

Endometriosis is a disease characterized by implants of endometrial tissue outside the uterine cavity and is strongly associated with infertility. Focal adhesion of endometrial tissue to the peritoneum is an indication of incipient endometr…

article 2014

CYP19 gene variant confers susceptibility to endometriosis-associated infertility in Chinese women

doi:10.1038/emm.2014.31 ·PMID:24968701

An aromatase encoded by the CYP19 gene catalyzes the final step in the biosynthesis of estrogens, which is related to endometriosis development. To assess the association of CYP19 gene polymorphisms with the risks of endometriosis, chocolat…