Andres Metspalu

No ORCID on file · 8 papers in corpus · active 2007-2023

Study types

  • article 4
  • other 3

Condition tags

  • endometriosis 6
  • infertility 4
  • irritable_bowel_syndrome 1
other 2023
Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus
Nature human behaviour ·doi:10.1038/s41562-023-01528-6

Identifying genetic determinants of reproductive success may highlight mechanisms underlying fertility and identify alleles under present-day selection. Using data in 785,604 individuals of European ancestry, we identified 43 genomic loci a…

article 2022
Endometriosis and irritable bowel syndrome: similarities and differences in the spectrum of comorbidities
Human Reproduction ·doi:10.1093/humrep/deac140

STUDY QUESTION: Do the spectrum and prevalence of comorbidities of endometriosis and irritable bowel syndrome (IBS) overlap? SUMMARY ANSWER: Despite several overlapping symptoms, the most significantly associated comorbidities of endometri…

2018
Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
·doi:10.1101/245506
other 2011
Polymorphisms in ESR1, ESR2 and HSD17B1 genes are associated with fertility status in endometriosis
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology ·doi:10.3109/09513590.2010.495434

OBJECTIVE: To investigate whether polymorphisms in genes involved in biosynthesis and signalling of sex steroids influence susceptibility to endometriosis and to infertility associated with it. MATERIALS AND METHODS: Patients with endometr…

article 2010
Genetic variations in vascular endothelial growth factor but not in angiotensin I-converting enzyme genes are associated with endometriosis in Estonian women
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2010.07.021
article 2010
Polymorphisms in MMP-2 and MMP-9 promoter regions are associated with endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2009.12.024
article 2009
Aromatase gene (CYP19A1) variants, female infertility and ovarian stimulation outcome: a preliminary report
Reproductive biomedicine online ·doi:10.1016/s1472-6483(10)60009-0
other 2007
Allelic estrogen receptor 1 (ESR1) gene variants predict the outcome of ovarian stimulation in in vitro fertilization
Molecular human reproduction ·doi:10.1093/molehr/gam035

The outcome of in vitro fertilization (IVF) depends substantially on the effectiveness of controlled ovarian hyperstimulation (COH) induced by administration of follicle-stimulating hormone (FSH). In COH, endogenously produced estrogens ext…