M. Bygdeman

The effects of prostaglandins (PG) E1 E2 E3 F1 alpha and F2 on the spontaneous motility of nonpregnant isolated human myometrium were compared with the effects of partially purified human seminal fluid prostaglandin. The synthetic PGs cause…

STUDY OBJECTIVE: To evaluate the effect of treatment with ethinylesteradiol-levonorgestrel or danazol on ovarian function, gonadotrophin release and endometrial development during the time when a pregnancy may occur following unprotected in…

The antiprogestin mifepristone, in combination with a prostaglandin analogue, has proved effective in terminating pregnancies and has been licensed for early abortion in three European countries and in China. This compound can also be used …

Seventeen healthy women aged 24-45 years with regular menstrual periods, proven fertility and not using steroidal contraceptives or IUD were recruited for the study. The volunteers were followed during one control, one treatment and one fol…

The sensitivity of myometrium to intrauterine administration of prostaglandin F2 alpha (PGF2a) and PGE2 was evaluated in 5 dysmenorrheic women during the secretory phase and during menstruation. In addition the effect of oral doses of 1 mg …

Clinical studies on the effect of locally administered prostaglandin E2 and F2alpha on the sensitivity and reactivity of the non-pregnant human uterus were performed in 16 volunteers. With the use of the flaccid microballoon technique, uter…

Summary. Progesterone has an inhibitory action on the spontaneous motility and pharmacological reactivity of isolated myometrial strips from women in early pregnancy. This effect is similar to that observed on isolated uterine preparations …

The effect of different prostaglandins present in human semen--PGE1 PGE2 PGE3 PGF1x PGF2x and a crude extract of human semen HSF-PG--were investigated and compared on human myometrium in vitro. The concentration of the prostaglandins in HSF…