Yang Y

OBJECTIVE: Per- and polyfluoroalkyl substances (PFAS) are omnipresent, persistent contaminants associated with rising ovarian cancer incidence; however, the molecular circuitry linking PFAS to ovarian tumorigenesis remains obscure. METHODS…

OBJECTIVE: To perform a preliminary, hypothesis-generating evaluation of the association between intraovarian injection of platelet-rich plasma (PRP) combined with peripheral blood mononuclear cells (PBMCs) and ovarian response parameters i…

OBJECTIVE: To study whether the impact of serum progesterone level on the day of hCG administration on reproductive outcomes varies across age groups and ovarian stimulation protocols in fresh in fresh in vitro fertilization (IVF) and intra…

BACKGROUND: Excessive activation of inflammatory responses and oxidative stress plays a critical role in the pathophysiology of endometriosis (EMs), which is characterized by ectopic lesion growth and chronic pelvic pain. However, effective…

Pelvic-organ prolapse (POP) is an age-associated disorder that is often accompanied by uterosacral ligament (USL) weakening and extracellular matrix (ECM) degradation; however, the upstream regulators linking fibroblast aging to ECM remodel…

BACKGROUND: Endometriosis is a chronic inflammatory disease characterized by immune microenvironment dysregulation, with the IL-33/ST2L signaling axis playing a crucial role in macrophage polarization and disease progression. Despite growin…

The causal role of established risk factors for premenstrual disorders (PMDs) remains unclear. We used Mendelian randomization (MR) to assess causality for eight known-risk factors identified through a literature review. Summary statistics …

Infertility constitutes a major global health concern, affecting approximately 17.5% of couples of reproductive age. Although advances in assisted reproductive technologies (ART) have expanded treatment options, success rates remain highly …

Ulcerative colitis (UC) is a challenging inflammatory disease with higher relapse and lower remission rates, urgently requiring effective and safe complementary treatment options. Apigenin (Api), a natural flavonoid from parsley and celery,…

Neuropathic pain (NP) is not merely simple persistent pain but a complex pathological condition mediated by dysregulation across multiple systems, including the neuro-immune-endocrine axis. As a high-intensity endogenous stressor, persisten…

OBJECTIVE: To explore the correlation between autoantibodies, ultrasonic endometrial receptivity parameters and early miscarriage in recurrent spontaneous abortion (RSA) patients during subsequent pregnancies, and to establish and validate …

BACKGROUND AND OBJECTIVE: Poly(ADP-ribose) polymerase inhibitors (PARPis) have fundamentally changed the treatment paradigm for patients with ovarian cancer, especially in tumors with homologous recombination deficiency (HRD). However, acqu…

Uterine infertility is a substantial global health challenge, imposing profound physical and emotional burdens on affected individuals, with endometrial injury being a key contributing factor. In this study, we report that platelet-derived …

BACKGROUND: In clinical practice, repeated oocyte retrieval cycles are often necessary for patients with diminished ovarian reserve (DOR). It has been hypothesized that the mechanical stimulation from the initial oocyte pick-up (OPU) proced…

Yang Jin,1,* Yongchao Pan,2,* Yilai Bao,1 Fei Xu,1 Yun Yang,1 Jingwen Fan,1 Yidan Jin,1 Yong Zhou,1 Ruijin Wu1,3 1Department of Obstetrics and Gynecology, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang,…

OBJECTIVE: Women with premenstrual disorder (PMD) display heightened sensitivity to hormonal changes and may be at risk for psychiatric disorders during other hormonally dynamic periods such as pregnancy and postpartum. While PMD has been l…

Ultraviolet (UV) radiation is a primary environmental factor responsible for skin photodamage, and exposure to UV rays is strongly linked to a variety of skin diseases. This study examined the prophylactic and therapeutic effects of Seed Oi…

BACKGROUND: The impact of the interval between consecutive testicular sperm aspiration (TESA) procedures on pregnancy outcomes of intracytoplasmic sperm injection (ICSI) in patients with obstructive azoospermia (OA) remains controversial. T…

OBJECTIVE: To describe the short-term safety, procedural characteristics, and clinical outcomes of ovarian vein embolization with adjunctive local sclerotherapy in a selected subgroup of women with pelvic venous disorder presenting with vul…

During spaceflight, the female reproductive system undergoes substantial adaptation to microgravity and faces an increased risk of reproductive impairment. Mammalian oocytes remain arrested for extended periods at the first meiotic prophase…

This systematic review and Bayesian network meta-analysis assessed the diagnostic accuracy of wearable digital technology (WDT) in monitoring women's fertility window compared to conventional methods. 8 databases were searched until January…

OBJECTIVES: To evaluate the efficacy of gonadotropin-releasing hormone agonist (GnRHa) combined with lauromacrogol sclerotherapy in preserving ovarian reserve and reducing pain in patients with ovarian endometriotic cysts (OECs). MATERIALS…

BACKGROUND: Ureteral reimplantation (UR) is the standard treatment for distal ureteral stricture, yet postoperative anastomotic restenosis impairs outcomes, with conventional imaging unable to quantify urinary tract obstruction and dysfunct…

Endometriosis (EMS) is characterized by a disrupted peritoneal immune microenvironment where alternatively activated anti-inflammatory (M2) macrophage polarization and impaired phagocytosis promote lesion survival. Single-cell RNA-sequencin…