Yoichiro Kamatani

No ORCID on file · 7 papers in corpus · active 2017-2023

Study types

  • article 2
  • meta-analysis 2
  • other 1
  • preprint 1
  • review 1

Condition tags

  • endometriosis 7
  • infertility 2
  • chronic_pelvic_pain 1
meta-analysis 2023
The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions
Nature genetics ·doi:10.1038/s41588-023-01323-z

Endometriosis is a common condition associated with debilitating pelvic pain and infertility. A genome-wide association study meta-analysis, including 60,674 cases and 701,926 controls of European and East Asian descent, identified 42 genom…

review 2021
Genetic overlap analysis of endometriosis and asthma identifies shared loci implicating sex hormones and thyroid signalling pathways
Human Reproduction ·doi:10.1093/humrep/deab254

STUDY QUESTION: Is there a shared genetic or causal association of endometriosis with asthma or what biological mechanisms may underlie their potential relationships? SUMMARY ANSWER: Our results confirm a significant but non-causal associat…

other 2020
A Mendelian randomization study identified obesity as a causal risk factor of uterine endometrial cancer in Japanese
Cancer science ·doi:10.1111/cas.14667

Causal inference is one of the challenges in epidemiologic studies. Gynecologic diseases have been reported to have association with obesity, however the causality remained controversial except for uterine endometrial cancer. We conducted t…

article 2020
Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality
Human genetics ·doi:10.1007/s00439-020-02223-6
article 2019
GWAS of five gynecologic diseases and cross-trait analysis in Japanese
European journal of human genetics : EJHG ·doi:10.1038/s41431-019-0495-1

We performed genome-wide association studies of five gynecologic diseases using data of 46,837 subjects (5236 uterine fibroid, 645 endometriosis, 647 ovarian cancer (OC), 909 uterine endometrial cancer (UEC), and 538 uterine cervical cancer…

preprint 2018
Large-scale genome-wide association meta-analysis of endometriosis reveals 13 novel loci and genetically-associated comorbidity with other pain conditions
·doi:10.1101/406967

Abstract Endometriosis is a common complex inflammatory condition characterised by the presence of endometrium-like tissue outside the uterus, mainly in the pelvic area. It is associated with chronic pelvic pain and infertility, and its pat…

meta-analysis 2017
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism
Nature communications ·doi:10.1038/ncomms15539

Endometriosis is a heritable hormone-dependent gynecological disorder, associated with severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely unknown. Here we perform a meta-analysis of 11 genome-wide ass…