Koutsilieris M — Endo Lab

article 1999

Immunohistochemical localization of insulin-like growth factor–binding protein-3 in eutopic and ectopic endometrial tissues

Fertility and sterility ·doi:10.1016/s0015-0282(99)00443-4

ObjectiveTo evaluate the expression of insulin-like growth factor-binding protein-3 (IGFBP-3) in the eutopic endometrium and in endometriotic lesions.DesignRetrospective immunohistochemical study.Patient(s)Twenty-five normal women and 39 wo…

article 1997

Association of protease activity against IGFBP-3 with peritoneal fluid mitogens: possible implications for the ectopic growth of endometrial cells in women with endometriosis.

Anticancer research

BACKGROUND: Recent data indicate the implication of an IGF/IGFBP/protease system in the development of ectopic implants of endometrium (endometriosis) in the pelvic cavity. MATERIAL AND METHODS: We characterized mitogens and protease(s) aga…

article 1995

N-terminal truncated forms of insulin-like growth factor binding protein-3 in the peritoneal fluid of women without laparoscopic evidence of endometriosis

Fertility and sterility ·doi:10.1016/s0015-0282(16)57362-2

ObjectiveTo characterize and purify peritoneal mitogens able to stimulate the proliferation of human endometrial cells in vitro.DesignPeritoneal fluids (PFs) from 50 patients were collected at laparoscopy and pooled (270 mL) for purificatio…

article 1993

Heparin-sepharose binding growth factors in peritoneal fluid of women with endometriosis

Fertility and sterility ·doi:10.1016/0020-7292(93)90243-p

OBJECTIVE: To characterize and to purify the growth substances for mouse embryo fibroblasts (NIH/3T3) and endometrial-like cells of the peritoneal fluid of women with endometriosis. DESIGN: A pool of 102 mL of peritoneal fluid (PF) collecte…

other 1991

Mitogen(s) for endometrial-like cells can be detected in human peritoneal fluid

Fertility and sterility ·doi:10.1016/s0015-0282(16)54660-3

OBJECTIVE: To characterize the presence of mitogen(s) in the peritoneal fluid (PF). DESIGN: Aliquots of PF aspirated at laparoscopy were assessed for mitogenic activity by the rate of [3H]-thymidine incorporation into the deoxyribonucleic …