Mechsner S

PURPOSE: Relugolix is an oral, non-peptide gonadotropin-releasing hormone receptor antagonist administered as once-daily combination therapy (relugolix-CT; 40 mg relugolix, 1 mg estradiol, 0.5 mg norethindrone acetate) to reduce endometrios…

Andrea S Lukes,1 Roberta Venturella,2 Krzysztof Dynowski,3 Rachel B Wagman,4 Julie S Perry,4 Yi Zhong,5 Viatcheslav G Rakov,6 Sylvia Mechsner,7 Neil P Johnson81Carolina Woman’s Research and Wellness Center, Durham, NC, USA; 2Department of C…

BACKGROUND: Endometriosis is associated with an increased risk of type I ovarian cancer, yet the prognostic relevance of concurrent endometriosis at diagnosis remains unclear. This cohort study evaluated whether endometriosis independently …

INTRODUCTION: Endometriosis (EM) is frequently associated with chronic pelvic pain (CPP) and dyspareunia, often linked to secondary pelvic floor dysfunction and hypertonicity. To evaluate whether the use of an intravaginal electromyography …

BACKGROUND: Given the challenges in early detection and diagnosis, understanding the molecular underpinnings of endometrioid ovarian cancer (EOC) is crucial for improving patient outcomes. This multi-level study provides a new perspective o…

Objective The objective of this revised official guideline, published by the German Society for Gynecology and Obstetrics (DGGG) and coordinated in the joint guidelines program of the DGGG, the Austrian Society for Gynecology and Obstetrics…

TARGET GROUP: Physicians interested in endometriosis and infertility as well as medical teams in reproductive medicine and endometriosis centers. OBJECTIVE: A practical guide for clinical decision-making. This guide was compiled by the wor…

Endometriosis is one of the most common causes of chronic pelvic or lower-abdominal pain, yet mechanisms, predictors, and patient-centered treatment pathways remain insufficiently defined. This article summarizes the situation in Germany an…

INTRODUCTION: A growing body of evidence suggests that women with endometriosis and adenomyosis are at an increased risk of complications during pregnancy and childbirth. Many of these complications are associated with increased blood loss.…

Endometriosis (EM) is a chronic inflammatory disease characterized by the growth of endometrial-like tissue outside the uterus, yet its molecular mechanisms remain poorly understood. This study investigated the expression of mucins (MUC1, M…

Endometriosis (EM) is a severe chronic inflammatory disease characterized by the presence of endometrium-like tissue outside the uterine cavity, causing pain and significantly reducing quality of life. Worldwide, around 10% of women of repr…

Christine Dawczynski,1 Jule Raschke,1 Lea Klein,1 Isabelle Schmidt,1 Svea Eichler,1 Marie Förster,1 Renata Voltolini Velho,2 Barbora Knappe-Drzikova,2 Sylvia Mechsner,2 Deborah Maier,3 Sven-Bastiaan Haange,4 Ulrike E Rolle-Kampczyk,4– 6 Mar…

BACKGROUND AND OBJECTIVE: Female-specific pain conditions such as dysmenorrhoea, endometriosis, and pain associated with pregnancy, childbirth, and menopause are highly prevalent and frequently impair quality of life. Superficial heat thera…

STUDY QUESTION: Does endometriosis affect the mental health of women using oral contraceptives? SUMMARY ANSWER: Among oral contraceptive users, women with endometriosis have a higher risk of depression compared to those without endometrios…

Endometriosis has a significant impact on the social, psychological, psychosomatic, and physical aspects of women's lives. There is increasing evidence that endometriosis has to be seen as a systemic and complex disorder with a multifactori…

BACKGROUND: Endometriosis is a chronic, inflammatory disease with considerable symptom load in affected female patients. Cyclic pain (associated with menstruation) dominates in most patients, but few patients suffer from persistent non-cycl…

Pain in endometriosis involves not only nociceptive but also neuropathic and neurogenic components, reflecting its complex nature. Histamine, a biogenic amine, has emerged as a critical mediator connecting inflammation and nerve sensitizati…

Endometriosis is a chronic inflammatory disease where endometrial-like lesions settle outside the uterus, resulting in extensive inflammatory reactions. It is a complex disease that presents with a range of symptoms, with pain and infertili…

BACKGROUND: In patients diagnosed with deep infiltrating endometriosis (DIE), foci of endometriosis are detected in mesorectal lymph nodes (LNs) after segmental bowel resection and in pelvic sentinel LNs. Lymph vessels (LVs) seem to be the …