Craig A. Witz — Endo Lab

review 2002

Endometriosis and infertility: is there a cause and effect relationship?

Gynecologic and obstetric investigation ·doi:10.1159/000049418

An association between endometriosis and infertility has long been noted. Endometriosis affects approximately 5% of the general population. In infertile women, the prevalence may be as high as 30%. Multiple studies, the majority of which ar…

article 2002

Menstrual endometrium and individual endometrial stromal and epithelial cells are unique in their ability to adhere to and invade peritoneal mesothelium

·doi:10.1016/s0015-0282(02)04047-5

review 2002

Pathogenesis of Endometriosis

Gynecologic and obstetric investigation ·doi:10.1159/000049425

Various theories have been promulgated to explain the pathogenesis of endometriosis. Interest in the genesis of the endometriotic lesion has been a focus since the earliest investigations. More recently, investigators have addressed aspects…

article 2002

The α2β1 and α3β1 integrins do not mediate attachment of endometrial cells to peritoneal mesothelium

·doi:10.1016/s0015-0282(02)03340-x

ObjectiveTo evaluate the possible role of mesothelial alpha(2)beta(1) and alpha(3)beta(1) integrins in the attachment of endometrial stromal cells (ESCs) and endometrial epithelial cells (EECs).DesignIn vitro study.SettingUniversity medical…

article 2001

Attachment of endometrial cells to peritoneum—facilitated? Reply of the authors:

·doi:10.1016/s0015-0282(01)01883-0

article 2001

Short-term culture of peritoneum explants confirms attachment of endometrium to intact peritoneal mesothelium

Fertility and sterility ·doi:10.1016/s0015-0282(00)01699-x

ObjectiveTo evaluate the initial adhesion of endometrium to the peritoneum.DesignDescriptive study using light and confocal laser-scanning microscopy, immunohistochemistry, and transmission electron microscopy.SettingUniversity-based labora…

article 2000

Expression of the α2β1 and α3β1 integrins at the surface of mesothelial cells: a potential attachment site of endometrial cells

Fertility and sterility ·doi:10.1016/s0015-0282(00)00701-9

ObjectiveTo localize alpha2beta1 and alpha3beta1 integrins in the cell membrane of peritoneal mesothelium in vivo and in vitro.DesignDescriptive study using confocal and two-photon laser-scanning microscopy.SettingUniversity-based laborator…

letter 2000

Interleukin-6: another piece of the endometriosis-cytokine puzzle

Fertility and sterility ·doi:10.1016/s0015-0282(99)00556-7

article 2000

Time Series Analysis of Transmesothelial Invasion by Endometrial Stromal and Epithelial Cells Using Three-Dimensional Confocal Microscopy

·doi:10.1016/s0015-0282(00)00778-0

article 1999

Current Concepts in the Pathogenesis of Endometriosis

Clinical Obstetrics and Gynecology ·doi:10.1097/00003081-199909000-00013

article 1999

Whole explants of peritoneum and endometrium: a novel model of the early endometriosis lesion

Fertility and sterility ·doi:10.1016/s0015-0282(98)00400-2

ObjectiveTo determine whether whole fragments of endometrium can adhere to peritoneum with intact mesothelium.DesignTissue culture and immunohistochemical study.SettingUniversity medical center.Patient(s)Reproductive-age women undergoing su…

review 1997

Pathogenesis

Seminars in reproductive endocrinology ·doi:10.1055/s-2008-1068749

There are many hypotheses concerning the pathogenesis of endometriosis, though no single theory can explain all cases. It is likely that several mechanisms are involved. Early studies concentrated on the histogenesis of the endometriotic le…

review 1995

Abnormal uterine bleeding

·doi:10.1016/s0025-7125(16)30071-2

Concerns about abnormal menstrual bleeding are a common reason for women to consult a primary care physician. The first step in the evaluation is to determine the patient's ovulatory status. Women with heavy bleeding but normal ovulatory cy…

article 1994

Characterization of Lymphocyte Subpopulations and T Cell Activation In Endometriosis

American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/j.1600-0897.1994.tb01110.x

PROBLEM: Numerous studies have characterized the lymphocyte subpopulations in normal eutopic endometrium and suggested a role for the cytokine secretory products of these lymphocytes in regulating endometrial cell proliferation and differen…