Ali Akoum

No ORCID on file · 88 papers in corpus
observational 2001
Correlation between decreased type-II interleukin-1 receptor and increased monocyte chemotactic protein-1 expression in the endometrium of women with endometriosis
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/j.8755-8920.2001.450401.x

PROBLEM: Monocyte chemotactic protein-1 (MCP-1), a potent inducer of macrophage recruitment and activation, is overexpressed in the eutopic endometrium of women with endometriosis. Eutopic endometrial cells of women with endometriosis secre…

other 2001
Decreased expression of the decoy interleukin-1 receptor type II in human endometriosis
The American Journal of Pathology ·doi:10.1016/s0002-9440(10)63990-9

Many of the biological changes occurring in the endometrium during the menstrual cycle bear a striking resemblance to those associated with inflammatory and reparative processes. Hence, it would not be surprising to find that cytokines know…

lab-animal 2001
Ectopic endometrial cells express high concentrations of interleukin (IL)-8 in vivo regardless of the menstrual cycle phase and respond to oestradiol by up-regulating IL-1-induced IL-8 expression in vitro
Molecular human reproduction ·doi:10.1093/molehr/7.9.859

Endometriosis, an oestrogen-dependent disorder affecting women of reproductive age, is associated with active angiogenesis and an increased recruitment of leukocyte into the peritoneal cavity where the implants often develop. The role of oe…

lab-animal 2000
Effect of hormonal agents on monocyte chemotactic protein-1 expression by endometrial epithelial cells of women with endometriosis
Fertility and sterility ·doi:10.1016/s0015-0282(00)01540-5

OBJECTIVE: To assess whether hormonal agents used in the medical treatment of endometriosis, such as danazol and GnRH agonist, exert direct regulatory action on monocyte chemotactic protein-1 (MCP-1) expression by endometrial epithelial cel…

lab-animal 2000
Estradiol amplifies interleukin-1-induced monocyte chemotactic protein-1 expression by ectopic endometrial cells of women with endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem.85.2.6348

Endometriosis, one of the most frequently occurring gynecological disorders, is estrogen dependent and is often associated with immunological changes. These include increased macrophage activation and infiltration into the endometriotic imp…

2000
Estradiol Amplifies Interleukin-1-Induced Monocyte Chemotactic Protein-1 Expression by Ectopic Endometrial Cells of Women with Endometriosis
·doi:10.1210/jc.85.2.896
observational 1999
Immunohistochemical localization of insulin-like growth factor-binding protein-3 in eutopic and ectopic endometrial tissues
Fertility and sterility ·doi:10.1016/s0015-0282(99)00443-4

OBJECTIVE: To evaluate the expression of insulin-like growth factor-binding protein-3 (IGFBP-3) in the eutopic endometrium and in endometriotic lesions. DESIGN: Retrospective immunohistochemical study. PATIENT(S): Twenty-five normal women…

lab-animal 1999
Physiological and cytogenetic characterization of immortalized human endometriotic cells containing episomal simian virus 40 DNA
The American Journal of Pathology ·doi:10.1016/s0002-9440(10)65376-x

The study of misplaced endometrial cells, which abnormally implant and grow outside the uterine cavity, is of considerable interest for the understanding of the pathophysiology of endometriosis. However, endometriotic cells, particularly ep…

1997
O-037 Increased expression of monocyte chemotactic protein-1 in the endometrium of women with endometriosis
·doi:10.1016/s0015-0282(97)90669-5
observational 1996
Increased monocyte chemotactic protein-1 level and activity in the peripheral blood of women with endometriosis. Le Groupe d'Investigation en Gynécologie
American journal of obstetrics and gynecology ·doi:10.1016/s0002-9378(96)70115-1

OBJECTIVE: Our purpose was to evaluate monocyte chemotactic protein-1 in the peripheral blood of women with and without endometriosis. STUDY DESIGN: Fifty-seven patients with endometriosis at laparoscopy done for infertility and pelvic pai…

lab-animal 1996
Secretion of interleukin-6 by human endometriotic cells and regulation by proinflammatory cytokines and sex steroids
Human Reproduction ·doi:10.1093/oxfordjournals.humrep.a019088

Endometriosis is generally associated with an immunoinflammatory process that takes place in the peritoneal cavity of patients. Interleukin (IL)-6, a multifunctional cytokine involved in numerous immunological and proliferative processes, h…

lab-animal 1995
Cytokine-induced secretion of monocyte chemotactic protein-1 by human endometriotic cells in culture. The Groupe d'Investigation en Gynécologie
American journal of obstetrics and gynecology ·doi:10.1016/0002-9378(95)90578-2

OBJECTIVE: Local secretion of chemotactic factors could contribute to the attraction of macrophages into the peritoneal cavity of women with endometriosis. The purpose of this study was to investigate the ability of endometriotic cells to p…

other 1995
N-terminal truncated forms of insulin-like growth factor binding protein-3 in the peritoneal fluid of women without laparoscopic evidence of endometriosis. Le groupe d'investigation en gynécologie
Fertility and sterility ·doi:10.1016/s0015-0282(16)57362-2

OBJECTIVE: To characterize and purify peritoneal mitogens able to stimulate the proliferation of human endometrial cells in vitro. DESIGN: Peritoneal fluids (PFs) from 50 patients were collected at laparoscopy and pooled (270 mL) for purif…