CA125-Associated Activated Partial Thromboplastin Time and Thrombin Time Decrease in Patients with Adenomyosis

Yang F, Wang Q, Ma R, Deng F, Liu J
2024 · W7026906596
article OA: green CC0
🔓 Open OA copy Full text JSON View on OpenAlex
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

In adenomyosis patients, elevated CA125 levels correlate with shortened activated partial thromboplastin time and thrombin time, indicating a potential hypercoagulable state.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This retrospective observational study measured CA125 and coagulation parameters (CA125-associated activated partial thromboplastin time [APTT] and thrombin time [TT]) in 200 adenomyosis patients, 240 uterine leiomyoma patients, and 81 cervical intraepithelial neoplasia (CIN-III) patients, comparing blood-sample results and analyzing associations with clinical symptoms. Adenomyosis patients had higher CA125 levels than the comparison groups, and APTT and TT were shorter in the adenomyosis group versus controls; multivariate logistic regression further linked adenomyosis with CA125 level and with shorter APTT and TT, and also associated these findings with menorrhagia and dysmenorrhea. Correlation analyses showed negative relationships between CA125 level and both APTT and TT. The paper does not explicitly state limitations in the provided text; overall, its methodology is retrospective and observational. This paper is centrally about adenomyosis—assessing how CA125-related changes in APTT and TT relate to hypercoagulability in adenomyosis patients.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Fanchun Yang, Qingying Wang, Rui Ma, Fangzhen Deng, Jie Liu Department of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Jie Liu, Department of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, No. 301, Yanchang Zhong Road, Shanghai, People’s Republic of China, Email [email protected]: Adenomyosis patients are in a hypercoagulable state, and studies have shown that carbohydrate antigen125 (CA125) may relate to the hypercoagulability and thrombosis of patients with adenomyosis, but there is still a lack of clarity regarding the changes in CA125-related coagulation indicators. This study was to explore the changes and influencing factors of CA125-related coagulation parameters in patients with adenomyosis.Methods: Retrospective observational study conducted on 200 patients with adenomyosis (AM group), 240 patients with uterine leiomyoma (LM group) and 81 patients with cervical intraepithelial neoplasia (CIN)-III (control group), of which the coagulation parameters were detected by clinical blood sample collection and statistical method analysis and informed consent was obtained.Results: The level of CA125 in the AM group was significantly higher than that in the LM group and control group. However, thrombin time (TT) shortened in the AM group when compared with the LM and control group. Activated partial thromboplastin time (APTT) in the AM group was shorter than in the control group. Multivariate logistic regression analysis found that adenomyosis was associated with CA125 level (OR=323.860, 95% CI 90.424– 1159.924, P< 0.001), APTT (OR=1.295, 95% CI 1.050– 1.598, P=0.016), TT (OR=0.642, 95% CI 0.439– 0.938, P=0.022), menorrhagia (OR=7.363, 95% CI 2.544– 21.315, P< 0.001), dysmenorrhea (OR=22.590, 95% CI 8.185– 62.347, P< 0.001). Correlation analysis revealed that APTT (r= − 0.207) and TT (r = − 0.174) were negatively correlated with the level of CA125.Conclusion: The shortening of CA125-related APTT and TT indicates that it is meaningful to detect coagulation parameters of patients with elevated CA125 levels early, dysmenorrhea and menorrhagia, and maybe further discover the hypercoagulability and prevent the occurrence of thrombus in adenomyosis.Keywords: adenomyosis, coagulation parameters, hypercoagulability, CA125, APTT, TT
Full text 2,606 characters · extracted from oa-html · click to expand
Journal of Multidisciplinary Healthcare (Jan 2024) CA125-Associated Activated Partial Thromboplastin Time and Thrombin Time Decrease in Patients with Adenomyosis Abstract Fanchun Yang, Qingying Wang, Rui Ma, Fangzhen Deng, Jie Liu Department of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Jie Liu, Department of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, No. 301, Yanchang Zhong Road, Shanghai, People’s Republic of China, Email [email protected]: Adenomyosis patients are in a hypercoagulable state, and studies have shown that carbohydrate antigen125 (CA125) may relate to the hypercoagulability and thrombosis of patients with adenomyosis, but there is still a lack of clarity regarding the changes in CA125-related coagulation indicators. This study was to explore the changes and influencing factors of CA125-related coagulation parameters in patients with adenomyosis.Methods: Retrospective observational study conducted on 200 patients with adenomyosis (AM group), 240 patients with uterine leiomyoma (LM group) and 81 patients with cervical intraepithelial neoplasia (CIN)-III (control group), of which the coagulation parameters were detected by clinical blood sample collection and statistical method analysis and informed consent was obtained.Results: The level of CA125 in the AM group was significantly higher than that in the LM group and control group. However, thrombin time (TT) shortened in the AM group when compared with the LM and control group. Activated partial thromboplastin time (APTT) in the AM group was shorter than in the control group. Multivariate logistic regression analysis found that adenomyosis was associated with CA125 level (OR=323.860, 95% CI 90.424– 1159.924, P< 0.001), APTT (OR=1.295, 95% CI 1.050– 1.598, P=0.016), TT (OR=0.642, 95% CI 0.439– 0.938, P=0.022), menorrhagia (OR=7.363, 95% CI 2.544– 21.315, P< 0.001), dysmenorrhea (OR=22.590, 95% CI 8.185– 62.347, P< 0.001). Correlation analysis revealed that APTT (r= − 0.207) and TT (r = − 0.174) were negatively correlated with the level of CA125.Conclusion: The shortening of CA125-related APTT and TT indicates that it is meaningful to detect coagulation parameters of patients with elevated CA125 levels early, dysmenorrhea and menorrhagia, and maybe further discover the hypercoagulability and prevent the occurrence of thrombus in adenomyosis.Keywords: adenomyosis, coagulation parameters, hypercoagulability, CA125, APTT, TT

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-html ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

adenomyosisdysmenorrhea

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2024) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

Source provenance

openalex
last seen: 2026-05-11T08:22:01.201230+00:00
License: CC0 · commercial use OK