[Role of estrogen, estrogen receptors, and aromatase in the pathogenesis of uterine adenomyosis]

Yu-Yan Zeng, Zeng YY, Yuyan Zeng, Yong-Ge Guan, Guan YG, Li KY, Kunyin Li, Kun-Yin Li
Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017 · vol. 37(3) , pp. 383–387 · doi:10.3969/j.issn.1673-4254.2017.03.18 · PMID:28377357 · PMC6780442 · W2977501917
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Elevated estrogen, estrogen receptor, and aromatase levels in adenomyosis lesions and eutopic endometrium promote cell proliferation via estrogen-ER binding, with ER also mediating effects through other pathways.

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Abstract

OBJECTIVE: To study the role of estrogen (E2), estrogen receptor (ER) and aromatase (P450arom) in the pathogenesis of uterine adenomyosis. METHODS: Paraffin-embedded specimens of the uterine tissue from patients with uterine adenomyosis and patients with cervical lesions (CIN; control) were examined for expressions of E2, ER and P450arom by immunohistochemistry and ELISA. The cells isolated from the lesions of patients with adenomyosis were cultured in vitro, and the changes in cell growth in response to treatments with E2, ER inhibitor, ER inhibitor + E2, estrogen deprivation, and estrogen deprivation+ ICI182780 were assessed using CCK-8 method. RESULTS: The expression levels of E2, ER, and P450arom were significantly higher in adenomyosis ectopic lesions and eutopic endometrium than in the myometrium and endometrium in the control group (P0.05), while the expression levels of ER in ectopic lesions was significantly higher than that in eutopic endometrium. The cell inhibition rates were similar between ER inhibitor group and ER inhibitor + Estrogen activation group (P>0.05), and was significantly higher in estrogen deprivation+ ER inhibitor group than in estrogen deprivation group (P<0.05). CONCLUSION: The high expression levels of E2, ER, and P450arom in adenomyosis ectopic lesions and eutopic endometrium promote uterine adenomyosis cell proliferation, in which process E2 combines with ER to execute its biological effect; ER also promotes the occurrence and development of uterine adenomyosis through other pathways.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Aromatase Estrogens Receptors, Estrogen Adenomyosis Adenomyosis Adenomyosis Aromatase Aromatase Cells, Cultured Cells, Cultured Endometrium Endometrium Endometrium Estrogens Estrogens Female Female Humans Humans

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