Leptin inhibits decidualization and enhances cell viability of normal human endometrial stromal cells

Print ISSN: 1107-3756 Online ISSN: 1791-244X International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease. International Journal of Oncology is an international journal devoted to oncology research and cancer treatment. Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery. Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine. Oncology Letters is an international journal devoted to Experimental and Clinical Oncology. Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology. International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis. Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology. Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition. Publishes open-access research on using epigenetics to advance understanding and treatment of human disease. An International Open Access Journal Devoted to General Medicine. Article - Authors: - Pages: 95-98|Published online on: July 1, 2003https://doi.org/10.3892/ijmm.12.1.95 - Expand metrics + Recent reports have demonstrated that the peritoneal fluid and serum concentrations of leptin are increased in women with endometriosis. However, the pathophysiological roles of leptin in endometriosis have not been well characterized. In this study, we examined the direct effects of leptin on normal human endometrial stromal cells using an in vitro decidualization assay system with 8-Br-cAMP, a decidualization inducer. No effects of leptin on cell viability and prolactin secretion were found in unstimulated endometrial stromal cells. Leptin dose-dependently enhanced the viability of stromal cells co-stimulated with 8-Br-cAMP and leptin while PRL secretion from the cells was significantly inhibited in a dose-dependent manner. As for 8-Br-cAMP-stimulated cells, leptin significantly enhanced their cell viability in a dose-dependent manner but not their PRL secretion. These results indicate that leptin enhances the cell viability of PRL-non-secreting 8-Br-cAMP-stimulated stromal cells, and that it inhibits the decidualization process of endometrial stromal cells. Increased leptin in endometriotic patients might play an antiapoptotic role in some activated ESCs in the peritoneal cavity to stimulate endometrial cell implantation, and might cause infertility by inhibiting stromal decidualization. Copy and paste a formatted citation Spandidos Publications style Tanaka T, Utsunomiya T, Bai T, Nakajima S and Umesaki N: Leptin inhibits decidualization and enhances cell viability of normal human endometrial stromal cells. Int J Mol Med 12: 95-98, 2003. APA Tanaka, T., Utsunomiya, T., Bai, T., Nakajima, S., & Umesaki, N. (2003). Leptin inhibits decidualization and enhances cell viability of normal human endometrial stromal cells. International Journal of Molecular Medicine, 12, 95-98. https://doi.org/10.3892/ijmm.12.1.95 MLA Tanaka, T., Utsunomiya, T., Bai, T., Nakajima, S., Umesaki, N."Leptin inhibits decidualization and enhances cell viability of normal human endometrial stromal cells". International Journal of Molecular Medicine 12.1 (2003): 95-98. Chicago Tanaka, T., Utsunomiya, T., Bai, T., Nakajima, S., Umesaki, N."Leptin inhibits decidualization and enhances cell viability of normal human endometrial stromal cells". International Journal of Molecular Medicine 12, no. 1 (2003): 95-98. https://doi.org/10.3892/ijmm.12.1.95