MRI-Based Volumetry of Uterine Structures Across the Menstrual Cycle in Patients and Controls for Early Adenomyosis Detection

Anatomy, Artificial Intelligence, MR, Segmentation, Outcomes Authors: C. Tappermann, B. Lassen-Schmidt, L. Siegler, T. Rüttinger, M. Fenske, M. B. Bauer, L. Kratzsch, S. Arndt, M. S. May DOI: 10.26044/ecr2026/C-23177 Purpose Adenomyosis is a common gynaecological condition, affecting more than 20 % of women during their reproductive years. It is characterised by the infiltration of endometrial gland and stroma into the myometrium. Clinically, it is frequently associated with uterine enlargement, pelvic pain, and can result in infertility [1, 2]. The RACOON FADEN project investigates the extraction of MRI-based uterine biomarkers for the early detection of adenomyosis, including volumetric differences of the myometrium (MM), junctional zone (JZ), and endometrium (EM) for patients and probands during menstruation and...

and materials Ethical approval for the RACOON FADEN study was obtained from the committees of all participating university hospitals, and the study was conducted in full accordance with the Declaration of Helsinki.Support for this work was provided by the German Bundesministerium für Bildung und Forschung via Netzwerk Universitätsmedizin (NUM 2.0, FKZ: 01KX2121).The dataset includes a cohort of 27 female patients and 27 female controls from nine German university hospitals. Each participant underwent MRI examination during both menstruation and ovulation, resulting in a total of 108 scans for...

During menstruation, mean uterine volumes in patients were 32.27 ± 12.65 ml for the MM, 13.57 ± 11.16 ml for the JZ, and 2.37 ± 1.76 ml for the EM. Comparable volumes were observed in controls, measuring 30.69 ± 14.90 ml for the MM, 14.45 ± 9.95 ml for the JZ, and 2.40± 4.08ml for the EM.At ovulation, uterine volumes remained similar between groups. Patients showed mean volumes of 32.64 ± 12.92 ml for the MM, 13.27 ± 5.77 ml for the JZ, and 3.15...

MRI-based volumetric analysis demonstrated stable MM and JZ volumes for both menstruation and ovulation, while the EM volume demonstrated a significant difference between both time points. No significant volumetric differences were observed between patients and controls, highlighting the need for additional imaging biomarkers. Personal information and conflict of interest C. Tappermann: Nothing to disclose B. Lassen-Schmidt: Nothing to disclose L. Siegler: Nothing to disclose T. Rüttinger: Nothing to disclose M. Fenske: Nothing to disclose M. B. Bauer: Nothing to disclose L. Kratzsch: Nothing to disclose S. Arndt: Nothing to disclose M. S. May: Nothing to disclose

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