{"paper_id":"fe1cac23-c35b-439e-ab38-4f63bd307efa","body_text":"ECR 2026 / C-23177\nMRI-Based Volumetry of Uterine Structures Across the Menstrual Cycle in Patients and Controls for Early Adenomyosis Detection\nCongress:\nECR 2026\nPoster Number:\nC-23177\nType:\nScientific Exhibit\nKeywords:\nAnatomy, Artificial Intelligence, MR, Segmentation, Outcomes\nAuthors:\nC. Tappermann, B. Lassen-Schmidt, L. Siegler, T. Rüttinger, M. Fenske, M. B. Bauer, L. Kratzsch, S. Arndt, M. S. May\nDOI:\n10.26044/ecr2026/C-23177\nPurpose\nAdenomyosis is a common gynaecological condition, affecting more than 20 % of women during their reproductive years. It is characterised by the infiltration of endometrial gland and stroma into the myometrium. Clinically, it is frequently associated with uterine enlargement, pelvic pain, and can result in infertility [1, 2]. The RACOON FADEN project investigates the extraction of MRI-based uterine biomarkers for the early detection of adenomyosis, including volumetric differences of the myometrium (MM), junctional zone (JZ), and endometrium (EM) for patients and probands during menstruation and...\nMethods and materials\nEthical approval for the RACOON FADEN study was obtained from the committees of all participating university hospitals, and the study was conducted in full accordance with the Declaration of Helsinki.Support for this work was provided by the German Bundesministerium für Bildung und Forschung via Netzwerk Universitätsmedizin (NUM 2.0, FKZ: 01KX2121).The dataset includes a cohort of 27 female patients and 27 female controls from nine German university hospitals. Each participant underwent MRI examination during both menstruation and ovulation, resulting in a total of 108 scans for...\nResults\nDuring menstruation, mean uterine volumes in patients were 32.27 ± 12.65 ml for the MM, 13.57 ± 11.16 ml for the JZ, and 2.37 ± 1.76 ml for the EM. Comparable volumes were observed in controls, measuring 30.69 ± 14.90 ml for the MM, 14.45 ± 9.95 ml for the JZ, and 2.40± 4.08ml for the EM.At ovulation, uterine volumes remained similar between groups. Patients showed mean volumes of 32.64 ± 12.92 ml for the MM, 13.27 ± 5.77 ml for the JZ, and 3.15...\nConclusion\nMRI-based volumetric analysis demonstrated stable MM and JZ volumes for both menstruation and ovulation, while the EM volume demonstrated a significant difference between both time points. No significant volumetric differences were observed between patients and controls, highlighting the need for additional imaging biomarkers.\nPersonal information and conflict of interest\nC. Tappermann:\nNothing to disclose\nB. Lassen-Schmidt:\nNothing to disclose\nL. Siegler:\nNothing to disclose\nT. Rüttinger:\nNothing to disclose\nM. Fenske:\nNothing to disclose\nM. B. Bauer:\nNothing to disclose\nL. Kratzsch:\nNothing to disclose\nS. Arndt:\nNothing to disclose\nM. S. May:\nNothing to disclose\nReferences\n[1]Agostinho, L., Cruz, R., Osório, F., Alves, J., Setúbal, A., & Guerra, A. (2017). MRI for adenomyosis: a pictorial review.Insights into imaging,8(6), 549-556.[2]Bazot, M., Cortez, A., Darai, E., Rouger, J., Chopier, J., Antoine, J. M., & Uzan, S. (2001). Ultrasonography compared with magnetic resonance imaging for the diagnosis of adenomyosis: correlation with histopathology.Human Reproduction,16(11), 2427-2433.[3]Mann, H. B., & Whitney, D. R. (1947). On a test of whether one of two random variables is stochastically larger than the other.The annals of mathematical statistics, 50-60.[4]Wilcoxon, F. (1945)....","source_license":"CC0","license_restricted":false}