Circulating miRNAs – a Potential Non-invasive Biomarker for Diagnosis of Endometriosis

Victoria Spasova, Zora Hammoudeh, Olga Antonova, Liliya Koleva, Draga Toncheva, Savina Hadjidekova, A. Kolev, Diana Hristova, Ventsislava Pencheva, S Hitrova, M Sokolov, Dejan Korunoski, Valentina Petkova, Milen Dimitrov, Silvia Nikolova, Vesela Karamisheva
In: Proceedings of the Bulgarian Academy of Sciences · 2024 · vol. 77(12) · doi:10.7546/crabs.2024.12.09 · W4405790499
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⚙ AI-generated summary by claude@2026-06, 2026-06-13 ⓘ

Researchers analyzed circulating miRNAs in 45 women and identified ten miRNAs with significant expression differences that may serve as non-invasive biomarkers for diagnosing endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-13 · read from full text ⓘ

The paper examines whether circulating microRNAs can serve as a non-invasive diagnostic and prognostic biomarker for endometriosis, addressing delays to diagnosis and the reliance on laparoscopy and histology. It studied 45 women (30 with endometriosis at different stages and 15 healthy controls) and analyzed the expression of 84 circulating miRNAs, nominating a panel based on the ten miRNAs with the most significant expression differences among early-stage endometriosis, advanced-stage endometriosis, and controls. A key limitation explicitly stated in the abstract text is that the study is based on a relatively small sample size. This paper is centrally about endometriosis — it focuses on identifying circulating miRNA panels for non-invasive diagnosis and prognostic use across stages of endometriosis.

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Abstract

Endometriosis is a debilitating disease affecting one in ten women worldwide. Due to several reasons the diagnosis is delayed for 7–11 years. Currently, the ultimate diagnostic procedure is laparoscopy followed by histological examination. The need for non-invasive biomarker is placed as a top priority according to the World Endometriosis Society. The present study includes 45 females – 30 patients with endometriosis at different stages and 15 healthy controls. An expression analysis of 84 circulating miRNAs was performed comparing between different groups of participants. Ten miRNAs with the most significant expression difference between females at early stage of endometriosis, advanced stage of endometriosis and healthy controls were nominated as a potential diagnostic and prognostic biomarker using a panel of miRNAs.
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Circulating miRNAs – a Potential Non-invasive Biomarker for Diagnosis of Endometriosis DOI: https://doi.org/10.7546/CRABS.2024.12.09Keywords: endometriosis, diagnosis, biomarker, miRNAAbstract Endometriosis is a debilitating disease affecting one in ten women worldwide. Due to several reasons the diagnosis is delayed for 7–11 years. Currently, the ultimate diagnostic procedure is laparoscopy followed by histological examination. The need for non-invasive biomarker is placed as a top priority according to the World Endometriosis Society. The present study includes 45 females – 30 patients with endometriosis at different stages and 15 healthy controls. An expression analysis of 84 circulating miRNAs was performed comparing between different groups of participants. Ten miRNAs with the most significant expression difference between females at early stage of endometriosis, advanced stage of endometriosis and healthy controls were nominated as a potential diagnostic and prognostic biomarker using a panel of miRNAs. Downloads Published How to Cite Issue Section License Copyright (c) 2024 Proceedings of the Bulgarian Academy of SciencesCopyright (c) 2022 Proceedings of the Bulgarian Academy of Sciences Copyright is subject to the protection of the Bulgarian Copyright and Associated Rights Act. The copyright holder of all articles on this site is Proceedings of the Bulgarian Academy of Sciences. If you want to reuse any part of the content, please, contact us.

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