Has ART Finally Got a Patient-Friendly Progesterone?
This editorial reviews progesterone's role in assisted reproduction, highlighting the benefits of synthetic progesterone and a new subcutaneous formulation over other options.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
This editorial discusses progesterone use for luteal phase support (LPS) in assisted reproduction, comparing progesterone preparations and addressing evidence from a Cochrane review that synthetic progesterone is favored over micronized progesterone, while hCG-based approaches are associated with higher ovarian hyperstimulation syndrome (OHSS) risk. It summarizes clinical trial results suggesting that aqueous progesterone administered subcutaneously can provide progesterone exposure sufficient for endometrial transformation and shows noninferior implantation and live birth outcomes versus vaginal progesterone, with similar safety and tolerability. A key limitation acknowledged in the text is that the optimal progesterone route and duration remain unclear, and that earlier trials have had mixed or “paradoxical” findings for some progesterone forms. This paper is not about endometriosis or adenomyosis and does not explicitly discuss either condition, though it relates to endometriosis/adenomyosis research as it is included in the corpus via a keyword match on progesterone and reproductive endometrial physiology.
Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works
My notes (saved in your browser only)
Citation neighborhood (sparse)
Too few in-corpus citations on either side for a chart; here are the lists.
Cites (3)
- Luteal phase support for assisted reproduction cycles 2015
- A comparative, randomized study of three different progesterone support of the luteal phase following IVF/ET program 1995
- Use of Crinone∗ vaginal progesterone gel for luteal support in in vitro fertilization cycles 1999
Cited by (2)
References (41)
- A comparative, randomized study of three different progesterone support of the luteal phase following IVF/ET program via openalex
- Luteal phase support for assisted reproduction cycles via openalex
- Use of Crinone∗ vaginal progesterone gel for luteal support in in vitro fertilization cycles via openalex
- W1986085565 via openalex
- W1992265932 via openalex
- W1996851025 via openalex
- W2015301325 via openalex
- W2032904118 via openalex
- W2035670423 via openalex
- W2037449545 via openalex
- W2037480258 via openalex
- W2040458748 via openalex
- W2041149571 via openalex
- W2045942412 via openalex
- W2066825099 via openalex
- W2068796004 via openalex
- W2085754255 via openalex
- W2093423899 via openalex
- W2108479208 via openalex
- W2129885967 via openalex
- W2132631445 via openalex
- W2134043108 via openalex
- W2138440840 via openalex
- W2143186752 via openalex
- W2167191293 via openalex
- W2167852330 via openalex
- W2172288304 via openalex
- W2242559056 via openalex
- W2255856286 via openalex
- W2304832397 via openalex
- W2334083862 via openalex
- W2413921334 via openalex
- W2753762701 via openalex
- W3125832290 via openalex
- W4210986798 via openalex
- W4285719527 via openalex
- W4294915367 via openalex
- W84583857 via openalex
- W6980583568 via openalex
- W1557425108 via openalex
- W1907235146 via openalex
Cited by (2)
Source provenance
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00