Association of the Estrogen Receptor-α Gene Polymorphism with the Risk of Endometriosis in Korean Women

Sa Ra Lee, Sung Eun Hur, Hye Sung Moon, Hyung‐Lae Kim, Hye Won Chung
In: The Ewha Medical Journal · 2003 · vol. 26(2) , pp. 91 · doi:10.12771/emj.2003.26.2.91 · W2259375010
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⚙ AI-generated summary by qwen3.7-flash, 2026-09-13 ⓘ

This study found no significant difference in estrogen receptor-α PvuII genetic polymorphism distribution between Korean women with endometriosis and controls, indicating no association with disease development.

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This study investigated whether genetic polymorphisms in the estrogen receptor-alpha gene are associated with endometriosis risk among Korean women. The researchers analyzed DNA samples from 136 patients with histopathologically confirmed stage III or IV endometriosis and compared them against a control group of 251 women without the condition using PCR and RFLP techniques. The results showed no significant difference in the distribution of PvuII genotypes between the patient and control groups, indicating that this specific genetic variation is not linked to disease development in this population. This paper is centrally about endometriosis, specifically examining the role of estrogen receptor-alpha genetics in its pathogenesis within a Korean cohort.

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Abstract

Objective To investigate whether polymorphism of gene encoding estrogen receptor-α is associated with the risk of endometriosis in Korean women. Material and Methods We investigated 136 patients with histopathologically confirmed endometriosis rAFS stage III/IV and 251 control group women who were surgically proven to have no endometriosis. Polymerase chain reaction(PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine each participant's estrogen receptor-α genotype. Results The distridution according to PvuII genetic polymorphism of estrogen receptor-α were as follows. PP, Pp and pp were 14.7%(20 women), 39.0%(53 women) and 46.3%(63 women) in the study group and 13.9%(35 women), 38.6%(98 women) and 47.4%(119 women) in the control group, respectively. There was no significant difference between the study group and the control group. Conclusion The results suggest that estrogen receptor-α genetic polymorphism may not be associated with the development of endometriosis in Korean women.
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Objective

To investigate whether polymorphism of gene encoding estrogen receptor-α is associated with the risk of endometriosis in Korean women. -

Material and methods

We investigated 136 patients with histopathologically confirmed endometriosis rAFS stage III/IV and 251 control group women who were surgically proven to have no endometriosis. Polymerase chain reaction(PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine each participant's estrogen receptor-α genotype. -

Results

The distridution according to PvuII genetic polymorphism of estrogen receptor-α were as follows. PP, Pp and pp were 14.7%(20 women), 39.0%(53 women) and 46.3%(63 women) in the study group and 13.9%(35 women), 38.6%(98 women) and 47.4%(119 women) in the control group, respectively. There was no significant difference between the study group and the control group. -

Conclusion

The results suggest that estrogen receptor-α genetic polymorphism may not be associated with the development of endometriosis in Korean women. Citations to this article as recorded by Association of the Estrogen Receptor-α Gene Polymorphism with the Risk of Endometriosis in Korean Women Association of the Estrogen Receptor-α Gene Polymorphism with the Risk of Endometriosis in Korean Women

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endometriosis

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