{"paper_id":"fa68ced2-1aec-4aed-b29d-f33ce405d268","body_text":"- HOME\n- Ewha Med J\n- Volume 26(2); 2003\n- Article\nOriginal Article\n2003;26(2):91-96.\nPublished online: June 30, 2003\nDepartment of Obstetrics and Gynecology, College of Medicine, Ewha Medical Research Center, Ewha Womans University, Korea.\n*Department of Biochemistry, College of Medicine Ewha Medical Research Center, Ewha Womans University, Korea.\nCopyright © 2003. Ewha Womans University School of Medicine\nThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.\n- 589 Views\n- 0 Download\n-\nObjective To investigate whether polymorphism of gene encoding estrogen receptor-α is associated with the risk of endometriosis in Korean women.\n-\nMaterial and Methods We investigated 136 patients with histopathologically confirmed endometriosis rAFS stage III/IV and 251 control group women who were surgically proven to have no endometriosis. Polymerase chain reaction(PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine each participant's estrogen receptor-α genotype.\n-\nResults The distridution according to PvuII genetic polymorphism of estrogen receptor-α were as follows. PP, Pp and pp were 14.7%(20 women), 39.0%(53 women) and 46.3%(63 women) in the study group and 13.9%(35 women), 38.6%(98 women) and 47.4%(119 women) in the control group, respectively. There was no significant difference between the study group and the control group.\n-\nConclusion The results suggest that estrogen receptor-α genetic polymorphism may not be associated with the development of endometriosis in Korean women.\nCitations to this article as recorded by\nAssociation of the Estrogen Receptor-α Gene Polymorphism with the Risk of Endometriosis in Korean Women\nAssociation of the Estrogen Receptor-α Gene Polymorphism with the Risk of Endometriosis in Korean Women","source_license":"CC0","license_restricted":false}