Danazol Induced Thrombocytopenia.

Kaichiro Yamamoto, K Yamamoto, H Hoshiai, Hiroshi Hoshiai, K Tsubaki, Kazuo Tsubaki, Y Kasano, Yuri Kasano, Kenji Shimizu, K Shimizu, A Horiuchi, Atsushi Horiuchi
The Tohoku journal of experimental medicine · 1997 · vol. 182(3) , pp. 249–252 · doi:10.1620/tjem.182.249 · PMID:9362107 · W2037672445
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

A patient developed severe thrombocytopenia and purpura upon initiating danazol treatment for an ovarian cyst, with symptoms recurring upon rechallenge, indicating drug-induced immune thrombocytopenic purpura.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This case report describes a 34-year-old woman treated with danazol 400 mg/day for a presumed endometrial cyst/left ovarian cyst, who developed gingival bleeding and purpura the day after a total dose of only 600 mg. Laboratory testing led to a diagnosis of immune thrombocytopenic purpura, and her platelet count increased after methylprednisolone treatment, but thrombocytopenia recurred rapidly when danazol was re-administered, with platelets dropping to 5,000/mm3. A limitation is that the evidence is confined to a single patient and a temporal association without broader mechanistic or comparative assessment. Relevance to endometriosis: the cyst was clinically diagnosed as an endometrial cyst and later histologically confirmed as an endometrial cyst, making the case directly related to endometriosis/endometrioma.

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Abstract

A 34-year-old woman with a left ovarian cyst (clinically diagnosed as endometrial cyst) was treated with 400 mg of danazol per day. On the next day, after a total dose of only 600 mg of danazol, gingival bleeding and purpura occurred. Her laboratory findings were as follows: platelet count 1000/ mm3 hematocrit 39%, WBC 7300/mm3 and RBC 466 x 10(4)/mm3. Immune thrombocytopenic purpura (ITP) was diagnosed, and she was treated with 40 mg of methylprednisolone per day for 19 days. Her platelet count increased to 130,000/ mm3. Her left ovarian cyst was extirpated surgically, and the histological diagnosis was endometrial cyst. Danazol at 400 mg per day was therefore again administered. On the next day, she complained of gingival bleeding and purpura again, and her platelet count was 5000/mm3. We diagnosed this case as danazol induced thrombocytopenia.

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Condition tags

endometriosis

MeSH descriptors

Danazol Purpura, Thrombocytopenic Adult Danazol Endometriosis Endometriosis Endometriosis Female Gingival Hemorrhage Gingival Hemorrhage Humans Ovarian Cysts Ovarian Cysts Ovarian Cysts Prednisolone Prednisolone Purpura, Thrombocytopenic Purpura, Thrombocytopenic Purpura, Thrombocytopenic

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