The role of transforming growth factor β in cervical remodeling within the rat cervix

Tanya Dailey, Huiling Ji, Vit Long, Edward K. Chien
In: American Journal of Obstetrics and Gynecology · 2009 · vol. 201(3) , pp. 322.e1–322.e6 · doi:10.1016/j.ajog.2009.06.002 · PMID:19631925 · W2025704907
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This study investigated transforming growth factor beta's role in cervical remodeling in rats, finding it influences this process.

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Abstract

ObjectiveTransforming growth factor beta (TGFbeta) plays a central role in extracellular matrix remodeling. We hypothesized that TGFbeta signaling is involved in cervical remodeling. This study evaluated patterns within this signaling pathway.Study designThe cervices of nonpregnant and timed pregnant rats were obtained. Messenger ribonucleic acid (mRNA) expression of TGFbeta1, TGFbeta receptor 1 (TbetaR1), TbetaR2, and TbetaR3 was evaluated. Four animals were euthanized for each time point. Western blotting was performed for protein expression. Phosphorylated mothers against decapentaplegic (Smad)-2 and -3 phosphorylation was assessed to evaluate TGFbeta activation.ResultsTGFbeta1 mRNA increased through day 21 and declined on day 22 (analysis of variance, P = .001). TbetaR1 expression was unchanged. TbetaR2 and TbetaR3 mRNA expression was similar to TGFbeta1. TbetaR3 protein expression was similar to mRNA. Smad2 phosphorylation paralleled changes in TbetaR3.ConclusionComponents of the TGFbeta signaling pathway increase during pregnancy along with Smad2 activation. The decline on day 22 correlates with a transition to the ripening phase supporting a role in cervical remodeling.

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