Comparison of the effect of isotretionin and alitretionin on endometriotic implants and serum vascular endothelial growth factor level: an experimental study

Deniz Kulaksız, Deniz Kulaksiz, Cavit Kart, Süleyman Güven, Suleyman Guven, Kubra Akbulut, Kübra Akbulut, Ümit Çobanoğlu, Umit Cobanoglu, Orhan Deger, Orhan Değer
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2019 · vol. 35(4) , pp. 301–304 · doi:10.1080/09513590.2018.1526275 · PMID:30600729 · W2906977318
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Abstract

OBJECTIVE: To compare the effects of alitretionin and isotretionin on endometrial peritoneal implants and serum vascular endothelial growth factor (VEGF) levels. STUDY DESIGN: Forty-eight female Sprague Dawley rats were used. Initially surgical rat endometriosis model was done. The endometrial implant volume was measured and rats were randomly divided into four groups. Group 1: Control group (rats did not get any drug but having endometriotic implants), group 2: rats receiving po isotretionin 10 mg/kg per day for 10 d, group 3: rats receiving po isotretionin 20 mg/kg per day for 10 d and group 4: rats receiving po alitretionin 80 mg/kg per day for 10 d. After 1-week medication, rats were sacrificed and size, histopathology of endometriotic implant and levels of VEGF were evaluated. RESULTS: Volumes of peritoneal endometrial implants were significantly decreased in Group 2 and Group 3 compared with initial values. However, there were no significant changes in histopathological scores and serum VEGF levels in all groups. CONCLUSIONS: This study finding may suggest the possible medical treatment modality of isotretionin on endometriosis. However, alitretionin (potent retinoid) does not have potent regressive effect on endometriotic implants as in isotretionin.

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mesh:D004715endometriosis

MeSH descriptors

Alitretinoin Endometriosis Isotretinoin Vascular Endothelial Growth Factor A Alitretinoin Alitretinoin Animals Drug Evaluation, Preclinical Endometriosis Female Isotretinoin Isotretinoin Rats, Sprague-Dawley Vascular Endothelial Growth Factor A

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