Absence of effect of danazol on estrogen-induced luteinizing hormone release from rat hypothalamo-pituitary axis in vitro

Akira Miyake, Keiichi Tasaka, Toshihiro Aono
In: Contraception · 1983 · vol. 28(1) , pp. 87–91 · doi:10.1016/s0010-7824(83)80009-2 · PMID:6627947 · W1985301932
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This study investigated the effect of danazol on estrogen-induced luteinizing hormone release from the rat hypothalamo-pituitary axis in vitro and found no significant effect.

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Abstract

The effects of danazol on luteinizing hormone (LH) release by estradiol (E2) were examined in a sequential double chamber superfusion system by superfusing the mediobasal hypothalamus (MBH) and pituitary excised from normal female rats in diestrus. Administration of 3x10(-13) mole E2 caused a significant (p less than 0.05) increase of LH (80-220% above the pre-injection level) from the pituitary in series with MBH superfused with Medium 199 alone or Medium 199 containing 10(-4)M danazol. These data indicate that acute administration of danazol does not affect estrogen-induced LH release in rats.

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