Mismatch repair system in endometriotic tissue and eutopic endometrium of unaffected women.

Tiziana Grassi, Grassi T, Angelo Calcagno, Calcagno A, Marzinotto S, Stefania Marzinotto, Londero AP, Ambrogio P. Londero, Maria Orsaria, Maria ­Orsaria, Gioia Canciani, Gioia N Canciani, Canciani GN, Beltrami CA, Carlo Alberto Beltrami, Marchesoni D, D. Marchesoni, Diego Marchesoni, Mariuzzi L, Laura Mariuzzi
International journal of clinical and experimental pathology · 2015 · vol. 8(2) , pp. 1867–77 · PMID:25973079 · PMC4396318 · W2400345591
article OA: green CC0 ⤵ 11 in-corpus citations
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This study found a significant loss of mismatch repair proteins in the stromal component of endometriotic tissue and identified increased MSH2 expression as potentially involved in cellular proliferation.

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Abstract

OBJECTIVE: To test the immunohistochemical staining pattern of some mismatch repair (MMR) system proteins in endometriotic tissue (ET) and eutopic endometrium. METHODS: This was a retrospective study conducted at the Pathology and Obstetrics and Gynecology Departments of the Udine University Hospital. We analyzed 528 samples obtained from 246 patients affected by endometriosis and 71 samples from 71 patients with normal endometrium. A tissue microarray model was used to analyze the immunohistochemical expression of MMR system proteins. RESULTS: Significant loss of MMR proteins was found in the stromal component of ETs. We found MSH2 to be expressed at a higher level than any other MMR system proteins in eutopic endometrium and ETs, to be significantly correlated to Ki-67 expression in both stromal and glandular components of ETs, and to be expressed at a significantly higher level in ETs than in eutopic endometrium. When considering the subgroup of endometriosis with high recurrence rate and glandular cytoplasmic staining for aurora A kinase, we found MMR proteins expressed at a significantly higher level in these ETs than in other ETs and eutopic endometrium of unaffected women. CONCLUSIONS: We found significant loss of MMR proteins (known to be associated with microsatellite instability) in the stromal component of ETs. The group of ETs with glandular cytoplasmic staining for aurora A kinase had higher MMR protein expression, suggesting an increased activity of this system. Our result suggests a novel role of increased MSH2 expression in cellular proliferation of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

DNA Mismatch Repair Endometriosis Endometrium MutS Homolog 2 Protein Aurora Kinase A Aurora Kinase A Biomarkers Biomarkers Cell Proliferation Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Hospitals, University Humans Immunohistochemistry Italy Ki-67 Antigen

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