Treatments to Enhance Implantation

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This paper discusses clinical concerns regarding the probability of pregnancy and live birth for subfertile couples undergoing specific treatment modes.

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This Springer chapter reviews treatment approaches aimed at enhancing human embryo implantation in the context of subfertility, focusing largely on assisted reproduction and the endocrine and embryo–endometrium factors that affect implantation success. It synthesizes findings from studies on progesterone/estrogen balance, luteal support, timing and supplementation around oocyte recovery, and related causes of implantation failure and early pregnancy loss, while framing implantation as a determinant of both pregnancy and healthy live birth outcomes. A stated limitation is that the chapter is an overview of heterogeneous evidence rather than a single experimental study, and it does not provide uniform, study-specific caveats beyond referencing underlying work. Relevance to endometriosis: the chapter cites IVF outcomes in infertility associated with endometriosis (Matson et al., 1986) as part of the broader implantation-treatment discussion, though its main focus is general treatments to enhance implantation.

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Abstract

In treating couples with subfertility the clinician will be concerned with: (a) the chance of pregnancy for the treatment mode applied and (b) the chance that the pregnancy will end in the birth of a healthy live infant. Preview Unable to display preview. Download preview PDF. Similar content being viewed by others

References

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Fertil Steril 37: 355–360 Johansson EDB (1971) Depression of progesterone levels in women treated with synthetic gestagens after ovulation. Acta Endocrinol 68: 779–792 Jones GS (1985) The role of luteal support in a programme for in vitro fertilization. In: Edwards RG, Purdy JM, Steptoe PC (eds) Implantation of the human embryo. Academic Press, London, pp 285–297 Leeton J, Trounson A, Jessup D (1985) Support of the luteal phase in in vitro fertilization programs: results of a controlled trial with intramuscular Proluton. J Vitro Fertil Embryo Transfer 2: 166–169 Lenton E, Sulaiman R, Sobowale O, Cooke ID (1982) The human menstrual cycle: plasma concentrations of prolactin, LH, FSH, oestradiol and progesterone in conceiving and non-conceiving women. J Reprod Fertil 65: 131–139 Lutjen P, Trounson A, Leeton J, Findlay J, Wood C, Renou P (1984) The establishment and maintenance of pregnancy using in vitro fertilization and embryo donation in a patient with primary ovarian failure. Nature 307: 174–176 Mahadevan MM, Leader A, Taylor PJ (1985) Effects of low-dose human chorionic gonadotrophin on corpus luteum function after embryo transfer. J Vitro Fertil Embryo Transfer 2: 190–194 Matson PL, Yovich JL (1986) The treatment of infertility associated with endometriosis by in-vitro fertilization. Fertil Steril 46: 432–434 Matson PL, Blackledge DG, Richardson PA, Turner SR, Yovich JM, Yovich JL (1986) Pregnancies after pronuclear stage transfer. Med J Aust 146: 60 O’Neill C, Ferrier AJ, Vaughan J, Sinosich MJ, Saunders DM (1985) Causes of implantation failure after in-vitro fertilization and embryo transfer. Lancet ii: 615 Psychoyos A, Mantel D (1985) Embryo-endometrial reactions at implantation. In: Edwards RG, Purdy JM, Steptoe PC (eds) Implantation of the human embryo. Academic Press, London, pp 195–210 Radwanska E, Swyer GIM (1974) Plasma progesterone estimation in infertile women under treatment with clomiphene and chorionic gonadotrophin. J Obstet Gynaecol Br Cw1th 81: 107–112 Shelesnyak MC (1959) Histamine and the nidation of the ovum. In: Eckstein P (ed) Implantation of ova. Cambridge University Press, London, pp 84–88 Stanger JD, Yovich JL (1985) Reduced fertilization of human oocytes from patients with raised basal LH levels during the follicular phase. Br J Obstet Gynaecol 92: 385–393 Taylor PJ, Trounson AO, Besanko M, Burger HG, Stockdale J (1986) Plasma progesterone and prolactin changes in superovulated women before, during, and immediately after laparoscopy for in vitro fertilization and their relation to pregnancy. Fertil Steril 45: 680–686 Townsend SL, Brown JB, Johnstone JW, Adey FD, Evans JH, Taft HP (1966) Induction of ovulation. J Obstet Gynaecol Br Cwlth 73: 529–543 Trounson A, Howlett D, Rogers P, Hoppen HO (1986) The effect of progesterone supplementation around the time of oocyte recovery in patients superovulated for in vitro fertilization. Fertil Steril 45: 532–535 Yovich JL (1985) Embryo quality and pregnancy rates in in vitro fertilisation. Lancet is 283–284 Yovich JL (1988) Infertility and fertility: Female. In: Grudzinskas JG, Beedham T (eds) Treatment and prognosis: Obstetrics and gynaecology. Heinemann Medical Books, London, pp 31–48 Yovich JL, Matson PL (1988) Early pregnancy wastage following gamete manipulation. Br J Obstet Gynaecol. 95 (in press) Yovich JL, Stanger JD, Yovich JM, Tuvik A (1984) Assessment and hormonal treatment of the luteal phase of in vitro fertilization cycles. Aust NZ J Obstet Gynaecol 24: 125–130 Yovich JL, McColm SC, Yovich JM (1985a) Early luteal serum progesterone concentrations are higher in conception cycles. Fertil Steril 44: 185–189 Yovich JL, Willcox DL, Wilkinson SP, Poletti VM, Hahnel R (19856) Medroxyprogesterone acetate does not perturb the profile of steroid metabolites in urine during pregnancy. J Endocr 104: 453–459 Yovich JL, Yovich JM, Tuvik AI, Junk S, Bootsma B, Matson PL (1986) In-vitro fertilization applied for tubal and non-tubal causes of infertility. Asia-Oceania J Obstet Gynaecol 12: 483–488 Yovich JL, Tuvik AI, Matson PL, Willcox DL (1987) Ovarian stimulation for disordered ovulatory cycles. Asia-Oceania J Obstet Gynaecol 13: 457–463 Yovich JL, Turner Sr, Blackledge DG, Richardson PA, Draper R (1988) Medroxyprogesterone acetate therapy in early pregnancy has no significant fetal effects. Teratology (in press) Yovich JL, Matson PL, Blackledge DG, Turner SR, Richardson PA, Yovich JM, Edirisinghe WR (1988) The treatment of normospermic infertility by gamete intrafallopian transfer ( GIFT ). Br J Obstet Gynaecol 95: 361–366 Editor information Editors and Affiliations Rights and permissions Copyright information © 1988 Springer-Verlag Berlin Heidelberg About this chapter Cite this chapter Yovich, J.L. (1988). Treatments to Enhance Implantation. In: Chapman, M.G., Grudzinskas, J.G., Chard, T. (eds) Implantation. Springer, London. https://doi.org/10.1007/978-1-4471-3529-6_18 Download citation DOI: https://doi.org/10.1007/978-1-4471-3529-6_18 Publisher Name: Springer, London Print ISBN: 978-1-4471-3531-9 Online ISBN: 978-1-4471-3529-6 eBook Packages: Springer Book Archive

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