Clinical status of reproductive aged women with combined pathology of the uterus – leiomyoma and adenomyosis

In: Reproductive Endocrinology · 2019 · vol. 0(50) , pp. 51–55 · doi:10.18370/2309-4117.2019.50.51-55 · W2997558734
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This study examined 120 reproductive-aged women with combined uterine leiomyoma and adenomyosis, finding 100% had extragenital pathologies and complex metabolic disorders affecting disease course.

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This paper investigated the clinical status of 120 reproductive-aged women with combined uterine pathology consisting of uterine leiomyoma and adenomyosis, stratifying them into two groups: one with asymptomatic leiomyoma and higher-severity, actively symptomatic adenomyosis (group IA) and another with symptomatic leiomyoma and lower-severity adenomyosis with inactive clinical course (group IB). Using clinical assessment per Ukrainian Ministry of Health orders, the authors found that all women had comorbidities of mainly chronic course across a wide range of extragenital organs and systems, and that anamnestic data showed 100% frequency of combined and concomitant pathology of the female genital tract. They concluded that multiple factors, including complex metabolic disorders, may influence disease course, while explicitly limiting the work to describing clinical status rather than establishing causal mechanisms. This paper is centrally about endometriosis and/or adenomyosis — it focuses on adenomyosis combined with uterine leiomyoma and characterizes the clinical status and comorbidity patterns in affected reproductive-aged women.

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Abstract

Clinical assessment of the general status of patients with combined uterine pathology (leiomyoma (LM) and adenomyosis) has a practical importance for determining specific therapeutic tactics. The study of the general condition of reproductive aged women with this pathology allows determining of many factors that can affect the clinical course of disease.Purpose of the study was to investigate the clinical status of reproductive aged women who suffer from combined uterine pathology – LM and adenomyosis.Materials and methods. 120 women of reproductive age were examined. Group IA united 60 patients with combined uterine pathology – asymptomatic LM and nodal, diffuse, diffuse-focal adenomyosis III, IV degrees of severity with active clinical course; group IB united 60 patients with combined uterine pathology - symptomatic LM and diffuse, diffuse focal adenomyosis I, II degrees of severity with inactive clinical course. Examination was carried out in accordance with the orders of the Ministry of Health of Ukraine.Results. A study of the general status of reproductive aged women has revealed many factors that can affect the clinical course of disease. The study of nosological forms of extragenital pathology revealed a wide range of different organs and systems diseases, co-morbidities of mainly chronic course, varying severity in 100% of women. A number of somatic diseases can be both a cause and a consequence of gynecological pathology, especially hormonal etiology. Analysis of the anamnestic data on the transferred gynecological diseases showed 100% frequency of the combined and concomitant pathology of the female genital tract.Conclusions. Completed study involving reproductive aged women with combined uterine pathology (LM and adenomyosis) showed many factors that can affect the clinical course of disease. Obtained data indicate that there are complex metabolic disorders in the women’s body suffering from that combined uterine pathology.
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Materials

and methods. 120 women of reproductive age were examined. Group IA united 60 patients with combined uterine pathology – asymptomatic LM and nodal, diffuse, diffuse-focal adenomyosis III, IV degrees of severity with active clinical course; group IB united 60 patients with combined uterine pathology - symptomatic LM and diffuse, diffuse focal adenomyosis I, II degrees of severity with inactive clinical course. Examination was carried out in accordance with the orders of the Ministry of Health of Ukraine. Results. A study of the general status of reproductive aged women has revealed many factors that can affect the clinical course of disease. The study of nosological forms of extragenital pathology revealed a wide range of different organs and systems diseases, co-morbidities of mainly chronic course, varying severity in 100% of women. A number of somatic diseases can be both a cause and a consequence of gynecological pathology, especially hormonal etiology. Analysis of the anamnestic data on the transferred gynecological diseases showed 100% frequency of the combined and concomitant pathology of the female genital tract. Conclusions. Completed study involving reproductive aged women with combined uterine pathology (LM and adenomyosis) showed many factors that can affect the clinical course of disease. Obtained data indicate that there are complex metabolic disorders in the women’s body suffering from that combined uterine pathology.

References

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