Evaluation of adenomyosis after gonadotrophin-releasing hormone agonist therapy using ultrasound post-processing imaging: a pilot study

Szu‐Yuan Chou, Cindy Chan, Yu-Chieh Lee, Tzu-Ning Yu, Chii‐Ruey Tzeng, Chii-Ruey Tzeng, Chi-Huang Chen
The Journal of international medical research · 2020 · vol. 48(6) , pp. 300060520920056 · doi:10.1177/0300060520920056 · PMID:32536293 · W3035122083
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This pilot study used computer-aided grayscale histogram analysis of ultrasound images to assess myometrial texture differences before and after GnRH agonist treatment for adenomyosis in infertile women.

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Abstract

OBJECTIVE: We explored a method for the quantitative sonographic analysis of myometrial texture using computer-aided image analysis software to assess outcomes following treatment with gonadotrophin-releasing hormone (GnRH) agonist for adenomyosis in women with infertility. METHOD: Data for patients with ultrasound images of the myometrium obtained at Taipei Medical University Hospital from 1 September 2018 to 5 April 5 2019 were analyzed. Only 10 patients with 20 ultrasound images matched the eligibility criteria. The images were divided into pre-treatment (n = 10) and post-treatment images (n = 10) and quantitative grayscale histograms were obtained from the ultrasound images using publicly available ImageJ computer-aided image analysis software. We analyzed the differences between the pre- and post-treatment images using the Mann-Whitney test and compared the results with outcomes assessed by serum CA-125 levels. RESULTS: Image analysis of the grayscale histograms revealed significant differences between before and after treatment. The classification of the myometrium pre-treatment and post-treatment was similar using CA-125 and histogram grayscale analysis. CONCLUSION: Computer-aided image analysis of grayscale histograms of the myometrium obtained from ultrasound images is an alternative method for assessing myometrial conditions after GnRH agonist treatment in patients with adenomyosis.

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Condition tags

adenomyosisinfertility

MeSH descriptors

Adenomyosis Image Processing, Computer-Assisted Ultrasonography Adenomyosis Adenomyosis Adult CA-125 Antigen CA-125 Antigen Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Hormone Replacement Therapy Hormone Replacement Therapy Hormones Hormones Humans Image Processing, Computer-Assisted Leuprolide Leuprolide Myometrium

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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