Reduced levels of gamma-interferon secretion in response to chlamydial 60 kDa heat shock protein amongst women with pelvic inflammatory disease and a history of repeated Chlamydia trachomatis infections

J Debattista, Debattista J, Joseph Debattista, Peter Timms, P Timms, J Allan, John Allan, Allan J
Immunology letters · 2002 · vol. 81(3) , pp. 205–210 · doi:10.1016/s0165-2478(02)00036-6 · PMID:11947926 · W2003642807
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Women with pelvic inflammatory disease or repeated chlamydial infections secreted less gamma-interferon in response to a chlamydial heat shock protein compared to other groups.

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Abstract

Peripheral lymphocytes in uninfected fertile controls, women with various histories of Chlamydia trachomatis infection, pelvic inflammatory disease (PID) and infertility not due to C. trachomatis infection (endometriosis) were cultured overnight with PHA mitogen and the 60 kDa chlamydial heat shock protein. Plasma samples were then assayed for levels of gamma-interferon and IL-10 using a commercial ELISA system. Women with PID and those with a history of multiple C. trachomatis infections showed reduced gamma-interferon production in response to cHSP60, not seen in women infected only once and those with infertility due to other causes (endometriosis). Secretion of IL-10 in response to cHSP60 did not vary significantly across the various patient groups, though all patients showed elevated levels of total IL-10 compared with uninfected controls.

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MeSH descriptors

Bacterial Outer Membrane Proteins Chaperonin 60 Chlamydia Infections Chlamydia trachomatis Interferon-gamma Pelvic Inflammatory Disease Bacterial Outer Membrane Proteins Cells, Cultured Chaperonin 60 Chlamydia Infections Female Humans Infertility Infertility Interferon-gamma Interferon-gamma Interleukin-10 Interleukin-10 Lymphocyte Activation Lymphocytes

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