Serologic responses of infertile women to the 60-kd chlamydial heat shock protein (hsp60)

J N Arno, Arno JN, Janet N. Arno, Y Yuan, Ying Yuan, Yuan Y, Robert E. Cleary, Cleary RE, R E Cleary, Richard P. Morrison, R P Morrison, Morrison RP
Fertility and sterility · 1995 · vol. 64(4) , pp. 730–735 · doi:10.1016/s0015-0282(16)57847-9 · PMID:7672143 · W2407234227
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Infertile women with Chlamydia trachomatis-associated tubal infertility more frequently exhibited antibodies targeting amino acids 201-300 of chlamydial hsp60 compared to infertile women without tubal disease.

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Abstract

ObjectiveTo determine whether women with Chlamydia trachomatis-associated tubal infertility are more likely than other infertile women to have antibodies to a particular region of the 60-kd chlamydial heat shock protein, hsp60.DesignSerologic responses to the chlamydial hsp60 were examined in 43 infertile women seropositive for Chlamydia trachomatis, including 21 women with tubal infertility, 13 women with endometriosis, and 9 women with other causes of infertility. Antibody responses were localized to regions of hsp60 using five nonoverlapping recombinant polypeptides.ResultsSixteen women with tubal infertility had anti-hsp60 antibodies compared with seven women with endometriosis and two women with other causes of infertility. Antibodies of 11 women with tubal infertility reacted predominantly with a region of hsp60 containing amino acids (201 to 300) compared with 1 women without tubal infertility. In contrast, antibodies that localized to the carboxyl terminus, amino acids (401 to 544), were seen equally in all groups.ConclusionsAmong seropositive infertile women, antibodies that localized to amino acids (201 to 300) were immunodominant in those with tubal infertility but not in those with infertility due to other causes.

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Condition tags

endometriosis

MeSH descriptors

Antibodies, Bacterial Chaperonin 60 Chlamydia trachomatis Infertility, Female Adult Amino Acid Sequence Antibodies, Bacterial Antibody Formation Chaperonin 60 Chaperonin 60 Chaperonin 60 Chlamydia trachomatis Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Fallopian Tube Diseases Fallopian Tube Diseases Female Humans Infertility, Female

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